Competitive endogenous RNA (ceRNA) regulation network of lncRNA-miRNA-mRNA during the process of the nickel-induced steroidogenesis disturbance in rat Leydig cells
| Autor: | Qiannan E, Xueyan Gu, Rui Zhang, Jianhua Ma, Xiaoqin Gan, Li Su, Caixia Wang, Xiaotian Zhang, Li Zhang, Shuang Wang |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Messenger RNA Competing endogenous RNA RNA Leydig Cells Endogeny General Medicine Biology Toxicology Fold change Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Nickel 030220 oncology & carcinogenesis microRNA Animals Gene Regulatory Networks Testosterone Rats Wistar After treatment Cells Cultured |
| Zdroj: | Toxicology in vitro : an international journal published in association with BIBRA. 63 |
| ISSN: | 1879-3177 |
| Popis: | Nickel (Ni) is a ubiquitous environmental pollutant, which can disrupt the production of steroid in rat Leydig cells. Steroidogenesis can be affected by non-coding RNAs (ncRNAs), which operate in normal physiological processes. To date, however, very few studies have focused on whether ncRNAs are involved in Ni-induced steroidogenesis disturbance. The present study was designed to investigate the impact of NiSO4 on the regulation of RNA networks including long non-coding RNA (lncRNA), microRNA (miRNA), and mRNA in rat Leydig cells. After treatment with 1000 μmol/L NiSO4 for 24 h, 372 lncRNAs, 27 miRNAs (fold change>2, p 2, p |
| Databáze: | OpenAIRE |
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