Counselling for smoking cessation during pregnancy reduces tobacco-specific nitrosamine (NNAL) concentrations: A randomized controlled trial
| Autor: | Aristeidis M. Tsatsakis, Constantine I. Vardavas, Christos Rosolymos, Panagiotis Behrakis, Antonis Myridakis, George Farmakides, Maria Lyberi, Charalambos Chrelias, Manolis Tzatzarakis, Andriani Loukopoulou |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
NNAL medicine.medical_treatment media_common.quotation_subject Urine lcsh:Gynecology and obstetrics law.invention chemistry.chemical_compound Randomized controlled trial law Internal medicine tobacco-specific carcinogen Maternity and Midwifery medicine interventions lcsh:RG1-991 media_common lcsh:RT1-120 Pregnancy lcsh:Nursing business.industry Obstetrics and Gynecology Abstinence medicine.disease cognitivebehavioural smoking cessation carcinogen tobacco-specific chemistry Pediatrics Perinatology and Child Health Gestation Smoking cessation Analysis of variance pregnancy Cotinine business Research Paper |
| Zdroj: | European Journal of Midwifery European Journal of Midwifery, Vol 2, Iss November (2018) |
| ISSN: | 2585-2906 |
| Popis: | INTRODUCTION Smoking cessation during pregnancy is beneficial to both the mother and child. Our objective was to assess if an intensive smoking cessation intervention for pregnant women increases: a) rates of smoking cessation, and b) reduces exposure to tobacco-specific carcinogens during pregnancy. METHODS A two-group single-blinded parallel randomized controlled trial (RCT) was conducted involving 84 pregnant smokers in either a high intensity (n=42) or minimal contact control group (n=42). Women assigned to the high intensity smoking cessation intervention group received a single 30-minute behavioural counselling session and a tailored self-help booklet. The primary outcome measures were: 7-day point prevalence abstinence measured by selfreport and urine cotinine levels, and maternal tobacco specific carcinogens nitrosamine (NNAL) urine concentrations assessed at 32 weeks of gestation. RESULTS A significantly greater percentage of pregnant smokers quit smoking in the high intensity group compared to the low intensity control group (45.2% vs 21.4%; p=0.001). A significant decrease in urine cotinine concentrations was documented in the experimental group (-140.74 ± 361.70 ng/mL; p=0.004), with no significant decrease documented in the control group. A significant decrease in NNAL levels was also documented in the experimental group (158.17 ± 145.03 pg/mL before, 86.43 ± 112.54 pg/mL after; p=0.032) with no significant changes in the control group. CONCLUSIONS The high intensity intervention tested resulted in significantly greater cessation rates. Intensive smoking cessation interventions can be effective in reducing fetal exposure to NNAL. This is the first trial to report on NNAL tobacco-specific carcinogen concentrations before and after an intervention for smoking cessation during pregnancy. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT01210118. ABBREVIATIONS 5Αs: ask, advise, asses, assist, arrange; GHQ: general health questionnaire; ANOVA: analysis of variance; RCT: randomized control trials; NNAL: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. |
| Databáze: | OpenAIRE |
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