Bile duct evaluation of potential living liver donors with Gd-EOB-DTPA enhanced MR cholangiography: Single-dose, double dose or half-dose contrast enhanced imaging
| Autor: | Stefan Maderwald, Verena Steinweg, Michael Forsting, Arnold Radtke, Georgios C. Sotiropoulos, Tobias Schroeder, Sonja Kinner |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Gadolinium DTPA Male medicine.medical_specialty Cholangiopancreatography Magnetic Resonance media_common.quotation_subject Medizin Gd-EOB-DTPA Sensitivity and Specificity Cholangiography Image Interpretation Computer-Assisted Living Donors medicine Humans Contrast (vision) Radiology Nuclear Medicine and imaging media_common Dose-Response Relationship Drug medicine.diagnostic_test Double dose Bile duct business.industry Reproducibility of Results Magnetic resonance imaging General Medicine respiratory system Image Enhancement Liver Transplantation medicine.anatomical_structure Liver donors Female Bile Ducts Radiology Objective evaluation business |
| Zdroj: | European Journal of Radiology. 83:763-767 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2014.02.012 |
| Popis: | Introduction Detailed knowledge of the biliary anatomy is essential to avoid complications in living donor liver transplantation. The aim of this study was to determine the optimal dosage of Gd-EOB-DTPA for contrast-enhanced magnetic resonance cholangiography (ce-MRC) with reference to contrast-enhanced CT cholangiography (ce-CTC). Materials and methods 30 potential living liver donors (PLLD) underwent both ce-CTC and ce-MRC. Ten candidates each received single, double or half-dose Gd-EOB-DTPA. Ce-MRC images with and without inversion recovery pulses (T1w ± IR) were acquired 20–30 min after intravenous contrast injection. Image data was quantitatively and qualitatively reviewed by two radiologists based on a on a 5-point scale. Data sets were compared using a Mann–Whitney- U -test or Wilcoxon-rank-sum-test. Kappa values were also calculated. Results All image series provided sufficient diagnostic information both showing normal biliary anatomy and variant bile ducts. Ce-CTC showed statistically significant better results compared to all ce-MRC data sets. T1w MRC with single dose Gd-EOB-DTPA proved to be superior to half and double dose in subjective and objective evaluation without a statistically significant difference. Conclusions Ce-MRC is at any dosage inferior to ce-CTC. As far as preoperative planning of bile duct surgery is focused on the central biliary anatomy, ce-MRC can replace harmful ce-CTC strategies, anyway. Best results were seen with single dose GD-EOB-DTPA on T1w MRC+IR. |
| Databáze: | OpenAIRE |
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