Gut microbiota, inflammation, and molecular signatures of host response to infection
| Autor: | Yuanqing Fu, Xiao Yi, Congmei Xiao, Haihong Zhao, Fengzhe Xu, Bo Shen, Yu-ming Chen, Zelei Miao, Xue Cai, Hao Chen, Geng-dong Chen, Yi Zhu, Wenhua Ling, Tiannan Guo, Ju-Sheng Zheng, Menglei Shuai, Liang Yue, Jun Wang, Xiaomai Wu, Wanglong Gou, Zengliang Jiang, Mian-li Xiao |
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| Rok vydání: | 2021 |
| Předmět: |
Proteomics
Inflammation Biology Gut flora digestive system Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Immune system Metabolomics Genetics medicine Humans Molecular Biology Feces 030304 developmental biology 0303 health sciences Host (biology) COVID-19 biology.organism_classification Gastrointestinal Microbiome Immunology Dysbiosis medicine.symptom 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Journal of Genetics and Genomics. 48:792-802 |
| ISSN: | 1673-8527 |
| DOI: | 10.1016/j.jgg.2021.04.002 |
| Popis: | Gut microbial dysbiosis has been linked to many noncommunicable diseases. However, little is known about specific gut microbiota composition and its correlated metabolites associated with molecular signatures underlying host response to infection. Here, we describe the construction of a proteomic risk score based on 20 blood proteomic biomarkers, which have recently been identified as molecular signatures predicting the progression of the COVID-19. We demonstrate that in our cohort of 990 healthy individuals without infection, this proteomic risk score is positively associated with proinflammatory cytokines mainly among older, but not younger, individuals. We further discover that a core set of gut microbiota can accurately predict the above proteomic biomarkers among 301 individuals using a machine learning model and that these gut microbiota features are highly correlated with proinflammatory cytokines in another independent set of 366 individuals. Fecal metabolomics analysis suggests potential amino acid-related pathways linking gut microbiota to host metabolism and inflammation. Overall, our multi-omics analyses suggest that gut microbiota composition and function are closely related to inflammation and molecular signatures of host response to infection among healthy individuals. These results may provide novel insights into the cross-talk between gut microbiota and host immune system. |
| Databáze: | OpenAIRE |
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