Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study
Autor: | Kun-Yuan Tsai, Yi-Chih Hung, Hsuan-Ju Chen, Chia-Hung Chen, Wen-Chao Ho, Wei-Chih Liao, Yi-Hao Peng, Yu-Sheng Lin |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
endocrine system diseases
Databases Factual Physiology Blood Pressure 030204 cardiovascular system & hematology Vascular Medicine Cohort Studies 0302 clinical medicine Endocrinology immune system diseases Risk Factors Medicine and Health Sciences Medicine 030212 general & internal medicine Multidisciplinary Hazard ratio Venous Thromboembolism Middle Aged Physiological Parameters Hypertension Risk assessment Cohort study Research Article Adult medicine.medical_specialty Adolescent Endocrine Disorders Science Cardiology Taiwan Surgical and Invasive Medical Procedures Risk Assessment 03 medical and health sciences Young Adult Internal medicine Thromboembolism Diabetes Mellitus Humans cardiovascular diseases Obesity Risk factor Aged Proportional Hazards Models Retrospective Studies Heart Failure Type 1 diabetes business.industry Proportional hazards model Body Weight nutritional and metabolic diseases Biology and Life Sciences Retrospective cohort study medicine.disease Diabetes Mellitus Type 1 Dyslipidemia Age Groups Metabolic Disorders People and Places Population Groupings business human activities |
Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 1, p e0226997 (2020) |
ISSN: | 1932-6203 |
Popis: | Background It has been unclear whether diabetes mellitus (DM) is positively associated with a risk of venous thromboembolism (VTE). In addition, whether the risk of VTE is altered in patients with type 1 diabetes (T1DM) has rarely been explored. Aim We investigated whether patients with T1DM are at a relatively high risk of VTE development. Methods We retrieved data from the National Health Insurance Research Database of Taiwan to conduct this retrospective cohort study. The T1DM group consisted of 4967 patients diagnosed as having T1DM before 2003. The non-T1DM group comprised 19 868 age- and sex-matched enrollees without T1DM. Cox proportional hazard regression analysis was used to investigate the hazard ratio of VTE in patients with T1DM relative to those without T1DM. Results During a mean follow-up period of 8.61 years, the risk of VTE in the T1DM group was 5.33-fold higher than in the non-T1DM group after adjusting for dyslipidemia, hypertension, stroke, lower leg fracture or surgery, and obesity. Further stratified analysis revealed that the risk of VTE was significantly high in both sexes and in all age groups below the age of 60. Conclusion T1DM appears to be an independent risk factor for VTE development. |
Databáze: | OpenAIRE |
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