Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study

Autor: Kun-Yuan Tsai, Yi-Chih Hung, Hsuan-Ju Chen, Chia-Hung Chen, Wen-Chao Ho, Wei-Chih Liao, Yi-Hao Peng, Yu-Sheng Lin
Jazyk: angličtina
Rok vydání: 2020
Předmět:
endocrine system diseases
Databases
Factual
Physiology
Blood Pressure
030204 cardiovascular system & hematology
Vascular Medicine
Cohort Studies
0302 clinical medicine
Endocrinology
immune system diseases
Risk Factors
Medicine and Health Sciences
Medicine
030212 general & internal medicine
Multidisciplinary
Hazard ratio
Venous Thromboembolism
Middle Aged
Physiological Parameters
Hypertension
Risk assessment
Cohort study
Research Article
Adult
medicine.medical_specialty
Adolescent
Endocrine Disorders
Science
Cardiology
Taiwan
Surgical and Invasive Medical Procedures
Risk Assessment
03 medical and health sciences
Young Adult
Internal medicine
Thromboembolism
Diabetes Mellitus
Humans
cardiovascular diseases
Obesity
Risk factor
Aged
Proportional Hazards Models
Retrospective Studies
Heart Failure
Type 1 diabetes
business.industry
Proportional hazards model
Body Weight
nutritional and metabolic diseases
Biology and Life Sciences
Retrospective cohort study
medicine.disease
Diabetes Mellitus
Type 1
Dyslipidemia
Age Groups
Metabolic Disorders
People and Places
Population Groupings
business
human activities
Zdroj: PLoS ONE
PLoS ONE, Vol 15, Iss 1, p e0226997 (2020)
ISSN: 1932-6203
Popis: Background It has been unclear whether diabetes mellitus (DM) is positively associated with a risk of venous thromboembolism (VTE). In addition, whether the risk of VTE is altered in patients with type 1 diabetes (T1DM) has rarely been explored. Aim We investigated whether patients with T1DM are at a relatively high risk of VTE development. Methods We retrieved data from the National Health Insurance Research Database of Taiwan to conduct this retrospective cohort study. The T1DM group consisted of 4967 patients diagnosed as having T1DM before 2003. The non-T1DM group comprised 19 868 age- and sex-matched enrollees without T1DM. Cox proportional hazard regression analysis was used to investigate the hazard ratio of VTE in patients with T1DM relative to those without T1DM. Results During a mean follow-up period of 8.61 years, the risk of VTE in the T1DM group was 5.33-fold higher than in the non-T1DM group after adjusting for dyslipidemia, hypertension, stroke, lower leg fracture or surgery, and obesity. Further stratified analysis revealed that the risk of VTE was significantly high in both sexes and in all age groups below the age of 60. Conclusion T1DM appears to be an independent risk factor for VTE development.
Databáze: OpenAIRE
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