Anal Lymphogranuloma Venereum Infection Screening With IgA Anti-Chlamydia trachomatis-Specific Major Outer Membrane Protein Serology
| Autor: | J. S. A. Fennema, Servaas A. Morré, Henry J. C. de Vries, Arjen G. C. L. Speksnijder, Sander Ouburg, Vitaly Smelov, J. Pleijster, Ronald B. Geskus |
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| Přispěvatelé: | Faculteit der Geneeskunde, Amsterdam institute for Infection and Immunity, Amsterdam Public Health, Dermatology, Epidemiology and Data Science, Medical Microbiology and Infection Prevention, Pathology, CCA - Immuno-pathogenesis |
| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
Sexually transmitted disease Male Population Porins Chlamydia trachomatis Dermatology urologic and male genital diseases medicine.disease_cause Asymptomatic Sensitivity and Specificity Serology medicine Humans Mass Screening Chlamydiaceae Serologic Tests Homosexuality Male education education.field_of_study Anus Diseases biology business.industry Lymphogranuloma venereum Public Health Environmental and Occupational Health Chlamydia Infections biology.organism_classification medicine.disease Virology female genital diseases and pregnancy complications Immunoglobulin A Infectious Diseases Chlamydiales Area Under Curve Lymphogranuloma Venereum medicine.symptom business |
| Zdroj: | Sexually Transmitted Diseases, 37(12), 789-795. Lippincott Williams & Wilkins de vries, H J C, Smelov, V, Ouburg, S, Pleijster, J, Geskus, R B, Speksnijder, A G C L, Fennema, J S A & Morre, S A 2010, ' Anal Lymphogranuloma Venereum Infection Screening With IgA Anti-Chlamydia trachomatis-Specific Major Outer Membrane Protein Serology ', Sexually Transmitted Diseases, vol. 37, no. 12, pp. 789-795 . https://doi.org/10.1097/OLQ.0b013e3181e50671 Sexually transmitted diseases, 37(12), 789-795. Lippincott Williams and Wilkins Sexually Transmitted Diseases, 37(12), 789-795. Lippincott Williams and Wilkins |
| ISSN: | 0148-5717 |
| Popis: | Background: Anal lymphogranuloma venereum (LGV) infections, caused by Chlamydia trachomatis biovar L (Ct+/LGV+), are endemic among men who have sex with men (MSM). Anal non-LGV biovar Ct infections (Ct+/LGV-) can be eradicated with 1 week doxycycline, whereas Ct+/LGV+ infections require 3-week doxycycline. To differentiate Ct+/LGV+ from Ct+/LGV- infections, biovar-specific Nucleic Acid Amplification Test (NAAT) are standard, but also expensive and laborious. A chlamydia-specific serological assay could serve as an alternative test. Methods: MSM were screened for anal Ct+/LGV+ and Ct+/LGV- infections with a commercial nonspecific NAAT and an in house biovar L-specific NAAT. Serum samples were evaluated with chlamydia-specific anti-Major Outer Membrane Protein (MOMP) and antilipopolysaccharide assays of IgA and IgG classes. Asymptomatic patients were identified as: (1) no anal complaints or (2) no microscopic inflammation (i.e. |
| Databáze: | OpenAIRE |
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