New insights into the control of mRNA decapping

Autor: Bertrand Séraphin, Sylvie Camier, Ernesto Simon
Přispěvatelé: Centre de génétique moléculaire (CGM), Centre National de la Recherche Scientifique (CNRS), La Ligue contre le Cancer (Equipe Labellisée 2005) (LNCC), CNRS, Ministère de la Recherche (ACI BCMS)
Jazyk: angličtina
Rok vydání: 2006
Předmět:
RNA Caps
MESH: Endoribonucleases
Saccharomyces cerevisiae Proteins
MESH: Mutation
Biology
medicine.disease_cause
Biochemistry
03 medical and health sciences
MESH: RNA Caps
0302 clinical medicine
MESH: Saccharomyces cerevisiae Proteins
Endoribonucleases
Gene expression
medicine
Animals
Humans
MESH: Animals
MESH: Proteins
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
RNA
Messenger
MESH: Models
Genetic
Molecular Biology
030304 developmental biology
MESH: RNA
Messenger
Decapping
0303 health sciences
Messenger RNA
Mutation
Cap binding complex
MESH: Humans
Models
Genetic
Proteins
RNA
MESH: Schizosaccharomyces pombe Proteins
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
Yeast
Cell biology
Proteins metabolism
Schizosaccharomyces pombe Proteins
030217 neurology & neurosurgery
Zdroj: Trends in Biochemical Sciences
Trends in Biochemical Sciences, Elsevier, 2006, 31 (5), pp.241-3. ⟨10.1016/j.tibs.2006.03.001⟩
ISSN: 0968-0004
DOI: 10.1016/j.tibs.2006.03.001⟩
Popis: mRNA decapping irreversibly targets mRNAs for fast decay. Cap removal is catalyzed by decapping protein Dcp2 but also requires Dcp1. Recently, two groups have provided a first glimpse of the regulation mechanism of this crucial step in gene expression. Resolution of the yeast Dcp2 structure has enabled identification of the residues that are important for its interaction with Dcp1. However, the human decapping machinery seems to be more complex because a third component, Hedls, is required for a functional Dcp1-Dcp2 interaction.
Databáze: OpenAIRE
Externí odkaz: