Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
Autor: | Laura Beatriz Tauro, Monaise M. O. Silva, Moyra Machado Portilho, Patrícia S.S. Moreira, Thaiza S. F. Gonçalves, Gubio Soares Campos, Leile Camila Jacob-Nascimento, Guilherme S. Ribeiro, Mariana Kikuti, Viviane C. Santos, Rosângela O. Anjos, Uriel Kitron, Mitermayer G. Reis, André Siqueira, Perla M. Santana |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male 0301 basic medicine Microbiology (medical) medicine.medical_specialty Adolescent viruses 030106 microbiology Enzyme-Linked Immunosorbent Assay Infectious and parasitic diseases RC109-216 Disease Dengue virus Chronic arthralgia medicine.disease_cause Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Odds Ratio medicine Humans 030212 general & internal medicine Chikungunya Risk factor Child Disability business.industry Transmission (medicine) Cohort Infant virus diseases General Medicine Middle Aged Arthralgia Infectious Diseases Child Preschool Relative risk Chikungunya Fever Female Chronic Pain business Chikungunya virus Viral load Brazil |
Zdroj: | International Journal of Infectious Diseases, Vol 105, Iss, Pp 608-616 (2021) |
ISSN: | 1201-9712 |
Popis: | Objectives: To investigate risk factors for persistent arthralgia in patients with chikungunya, and describe its impact on daily activities. Methods: From September 2014 to July 2016, a surveillance study enrolled patients with acute febrile illness in Salvador, Brazil, and detected those with chikungunya virus infection using IgM enzyme-linked immunosorbent assay or reverse transcriptase polymerase chain reaction. Telephone follow-ups were performed to ascertain the progression of disease. Results: Of 153 followed cases, 65 (42.5%) reported chronic arthralgia that lasted >3 months, and 47 (30.7%) were still symptomatic at the time of the interview (approximately 1.5 years after symptom onset). Limitations in daily activities and mental distress were reported by 93.8% and 61.5% of those with chronic arthralgia, respectively. Female sex [risk ratio (RR) 1.79, 95% confidence interval (CI) 1.95-2.69] and age (RR 1.02 for each 1-year increase, 95% CI 1.01-1.03) were independent risk factors for chronic arthralgia. Chronic arthralgia was not associated with co-infection with dengue virus (RR 0.97, 95% CI 0.48-1.94) or chikungunya viral load at diagnosis (median chikungunya virus RNA of 5.60 and 5.52 log10 copies/μL for those with and without chronic arthralgia, respectively; P = 0.75). Conclusions: These findings reinforce the high frequency of chronic chikungunya arthralgia, and highlight the substantial disability associated with the persistence of pain. Development of novel strategies to mitigate the transmission of chikungunya virus and to provide long-term medical assistance for patients with chikungunya are needed urgently. |
Databáze: | OpenAIRE |
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