Tangeretin ameliorates bisphenol induced hepatocyte injury by inhibiting inflammation and oxidative stress
| Autor: | Satyanarayana Swamy Mruthinti, Asma Ashraf, Abdul Samad, Khalid A. Al-Ghanim, Muhammad Sarmad Shahab, Shahid Mahboob, Muhammad Umar Ijaz |
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| Rok vydání: | 2022 |
| Předmět: |
endocrine system
Antioxidant biology urogenital system Thiobarbituric acid medicine.medical_treatment Glutathione reductase Glutathione Pharmacology medicine.disease_cause chemistry.chemical_compound chemistry Catalase medicine TBARS biology.protein Alkaline phosphatase General Agricultural and Biological Sciences hormones hormone substitutes and hormone antagonists Oxidative stress |
| Zdroj: | Saudi Journal of Biological Sciences. 29:1375-1379 |
| ISSN: | 1319-562X |
| Popis: | Bisphenol A (BPA) is an industrial toxicant that can potentially damage the liver. Tangeretin (TGN) is a natural flavonoid that displays various pharmacological activities. This experiment was carried out to evaluate the protective effects of TGN against BPA-induced hepatic impairment in the male albino rat. Twenty-four male albino rats were equally divided into four different groups: control, BPA (100mg/kg), BPA+ TGN (100mg/kg+50mg/kg) and TGN (50mg/kg). BPA exposure significantly decreased the activities of catalase (CAT), superoxidase dismutase (SOD), peroxidase (POD), glutathione reductase (GSR), glutathione S-transferase (GST), and glutathione (GSH) content while substantially increasing the thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (H2O2) levels. A substantial increase in the levels of alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST) was also observed in BPA treated rats. Moreover, BPA significantly increased the inflammatory markers, including tumor necrosis factor-α (TNF-α), nuclear factor kappa-B (NF-κB), Interleukin-6 (IL-6), Interleukin-1β (IL-1β)levels, cyclooxygenase-2 (COX-2) activity, and histopathological damages. However, co-treatment with TGN efficiently minimized the BPA-induced biochemical, inflammatory, and histopathological impairments in rat liver. The present study shows that TNG has significant potential to avert BPA-induced liver damage to its antioxidant and anti-inflammatory properties. |
| Databáze: | OpenAIRE |
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