Preceding Viral Infections Do Not Imprint Long-Term Changes in Regulatory T Cell Function
| Autor: | Nikolas Rakebrandt, Nicole Joller, Felix Rost, Katharina Lambert |
|---|---|
| Přispěvatelé: | University of Zurich, Joller, Nicole |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adoptive cell transfer Regulatory T cell Immunology lcsh:Medicine Vaccinia virus chemical and pharmacologic phenomena 610 Medicine & health Biology Lymphocytic choriomeningitis CXCR3 10263 Institute of Experimental Immunology T-Lymphocytes Regulatory Article Virus Mice 03 medical and health sciences 0302 clinical medicine Immune system Vaccinia medicine Animals Arenaviridae Infections Humans Lymphocytic choriomeningitis virus lcsh:Science 1000 Multidisciplinary Multidisciplinary Effector lcsh:R FOXP3 hemic and immune systems medicine.disease Adoptive Transfer 3. Good health Disease Models Animal 030104 developmental biology medicine.anatomical_structure 570 Life sciences biology lcsh:Q Infection Immunologic Memory 030215 immunology |
| Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
| Popis: | Regulatory T cells (Tregs) maintain peripheral self-tolerance and limit immune mediated pathology. Like effector T cells, Tregs can specialize in TH1-dominated immune responses and co-express T-bet together with Foxp3. This allows for expression of CXCR3 and efficient homing to sites of TH1 responses. However, whether such functional specialization is paralleled by memory generation among Tregs is unknown. In this study, we investigated the ability of polyclonal Tregs to form functional memory in response to viral infection. Using adoptive transfer models to compare infection-experienced Tregs generated upon acute Lymphocytic Choriomeningitis Virus (LCMV) WE and Vaccinia Virus (VV) infections with naive Tregs, we observed no differences in their phenotype or their in vivo maintenance. When comparing functional properties of infection-experienced and naive Tregs, we found no differences in in vitro suppressive capacity nor in their ability to limit the effector response upon homologous, systemic or local re-challenge in vivo. Our results suggest that no functional Treg memory is generated in the context of systemic LCMV or VV infection, but we cannot rule out the possibility that the generation of Treg memory may be possible in other contexts. |
| Databáze: | OpenAIRE |
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