Oxidative Phosphorylation Dysfunction Modifies the Cell Secretome

Autor: Ana Vela-Sebastián, Sonia Emperador, Ester López-Gallardo, Patricia Meade, Cecilia Jimenez-Mallebrera, Eduardo Ruiz-Pesini, Nuria Garrido-Pérez, Eldris Iglesias, M. Pilar Bayona-Bafaluy, Julio Montoya
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Vascular Endothelial Growth Factor A
Mitochondrial DNA
Growth Differentiation Factor 15
FGF21
interleukine-6
Cell
fibroblast growth factor 21
Review
Oxidative phosphorylation
mitochondrial DNA
Biology
DNA
Mitochondrial
Oxidative Phosphorylation
Catalysis
Inorganic Chemistry
lcsh:Chemistry
chemistry.chemical_compound
medicine
Humans
oxidative phosphorylation system
Genetic variability
Physical and Theoretical Chemistry
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
mitochondrial diseases
Secretory Pathway
vascular endothelial growth factor
Interleukin-6
Organic Chemistry
biomarkers
General Medicine
Computer Science Applications
Cell biology
Fibroblast Growth Factors
Vascular endothelial growth factor
Circulating biomarkers
secretome
medicine.anatomical_structure
chemistry
lcsh:Biology (General)
lcsh:QD1-999
GDF15
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 3374, p 3374 (2020)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: Mitochondrial oxidative phosphorylation disorders are extremely heterogeneous conditions. Their clinical and genetic variability makes the identification of reliable and specific biomarkers very challenging. Until now, only a few studies have focused on the effect of a defective oxidative phosphorylation functioning on the cell’s secretome, although it could be a promising approach for the identification and pre-selection of potential circulating biomarkers for mitochondrial diseases. Here, we review the insights obtained from secretome studies with regard to oxidative phosphorylation dysfunction, and the biomarkers that appear, so far, to be promising to identify mitochondrial diseases. We propose two new biomarkers to be taken into account in future diagnostic trials.
Databáze: OpenAIRE
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