Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells
| Autor: | Bibikova Mv, M. Kh. Levitman, L. N. Kublik, N. A. Spiridonova, A. F. Korystova, Yu. N. Korystov, Vera V. Shaposhnikova |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Antineoplastic Agents Apoptosis Fungus Complex Mixtures Biology General Biochemistry Genetics and Molecular Biology Inhibitory Concentration 50 Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Tumor Cells Cultured medicine Animals Humans Masoprocol Lipoxygenase Inhibitors Lymphocytes IC50 Incubation Cell Nucleus DNA Neoplasm General Medicine respiratory system medicine.disease biology.organism_classification Molecular biology Nordihydroguaiaretic acid 030104 developmental biology medicine.anatomical_structure chemistry Biochemistry Mice Inbred DBA 030220 oncology & carcinogenesis Cordyceps Nucleus DNA Lymphoid leukemia |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 163:330-333 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-017-3796-9 |
| Popis: | We studied the effect of lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and fungus Lecanicillum lecanii extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors was evaluated by changes in cell number, trypan blue staining, nucleus damage, and changes in cell distribution by DNA content after 22-h incubation. NDGA and fungus extract induced apoptotic death of lymphatic leukemia cells, which was seen from nucleus damage and reduced DNA content in cells. IC50 for NDGA and fungus extract was 0.66 and 5.5 μg/ml, respectively. |
| Databáze: | OpenAIRE |
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