Diabetic neuropathy is associated with increased pain perception, low serum beta-endorphin and increase insulin resistance among Nigerian cohorts in Ekiti State
| Autor: | Adesola A. Oniyide, Gbenga Sunday Adeleye, Oyesanmi A. Fabunmi, Bamidele Victor Owoyele, O. O. Akintoye, Abimbola O. Akintoye, TH Raimi, David Daisi Ajayi, Ayodeji J. Ajibare |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Diabetic neuropathy Ischemic-induced pain model Veterinary medicine Gastroenterology Article Environmental science 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin resistance Internal medicine Threshold of pain medicine lcsh:Social sciences (General) lcsh:Science (General) Endogenous opioid Multidisciplinary Chronic pain Health sciences medicine.disease Biological sciences 030104 developmental biology Pain threshold chemistry β-Endorphin lcsh:H1-99 Analysis of variance Glycated hemoglobin 030217 neurology & neurosurgery Neuroscience Biomedical sciences lcsh:Q1-390 |
| Zdroj: | Heliyon, Vol 6, Iss 7, Pp e04377-(2020) Heliyon |
| ISSN: | 2405-8440 |
| Popis: | Introduction There has been an increase in the global prevalence of diabetic polyneuropathy and research evidence suggests that insulin resistance plays an important role in its development and prognosis. However, there seem to be a dearth of information in understanding the likely interplay between beta endorphin, insulin resistance and pain perception especially in the setting of painful diabetic neuropathy. Method This study recruited 120 volunteers divided into four groups (30 per group): group 1 healthy volunteer (control); group 2 DM type 2 without neuropathy (DM group); group 3 DM type 2 with painful neuropathy (DPN group); group 4 DM type 2 without painful neuropathy (DN). All subjects were evaluated for pain threshold and neuropathy using an ischemia-induced pain model and biothesiometer respectively. Their beta-endorphin, glycated hemoglobin, fasting plasma insulin, and HOMA values were determined and means compared using ANOVA. Result Serum beta-endorphin is significantly reduced in DN and DPN (∗p < 0.001) compared with the control and DM group. Also, DPN and DN patients have significantly increased insulin resistance compared to those without neuropathy (∗p < 0.001; ∗p < 0.0001 respectively). There is a significant positive correlation between the pain threshold and beta-endorphin in all the groups except DN group. The correlation between beta-endorphin and insulin resistance was negative and significant in control and DM groups only. Suggestive that the fact that insulin resistance plays an important role in diabetes polyneuropathy, does not alone explain the chronic pain perception noticed in the DPN patients. Conclusion The present study demonstrates that diabetic neuropathy patients have a poor endogenous opioid peptide system which is associated with increased pain perception and high insulin resistance. However, insulin resistance alone does not explain the chronic pain perception noticed in the DPN patients. Thus, further study is required. Diabetic neuropathy, β-Endorphin, Ischemic-induced pain model, Pain threshold, Insulin resistance, Environmental science, Biological sciences, Neuroscience, Veterinary medicine, Health sciences |
| Databáze: | OpenAIRE |
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