A randomized controlled trial of effectiveness of platelet-rich plasma gel and regular dressing on wound healing time in pilonidal sinus surgery: Role of different affecting factors
| Autor: | Ardeshir Ghavamzadeh, Anoshirvan Kazemnejad, Amir Hossein Norooznezhad, Hiva safar, Kamran Ali Moghaddam, Shayan Mostafaei, Saeed Mohamadi, Mohsen Nikbakht, Shirzad Nassiri |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Original article Time Factors Adolescent Pain law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Pilonidal Sinus Randomized controlled trial law Sinus disease Medicine Humans lcsh:QH301-705.5 lcsh:R5-920 Wound Healing business.industry Proportional hazards model Platelet-Rich Plasma General Medicine Sinus surgery Middle Aged Bandages Surgery Clinical trial Extended cox regression 030104 developmental biology lcsh:Biology (General) 030220 oncology & carcinogenesis Wound dressing Platelet-rich plasma Female business Wound healing lcsh:Medicine (General) |
| Zdroj: | Biomedical Journal Biomedical Journal, Vol 42, Iss 6, Pp 403-410 (2019) |
| ISSN: | 2320-2890 2319-4170 |
| Popis: | Background: The aim of this study was to assess the possible association between different factors such as age, sex, antibiotic consumption duration, angiogenesis and pain and “acceleration of wound healing” in pilonidal sinus patients after treating with platelet-rich plasma (PRP). Methods: In this clinical trial, 110 patients were randomly divided into treatment arm and control group. After surgery, control group underwent classic wound dressing and the treatment arm experienced PRP gel therapy. Before achieving complete healing, wound incisional biopsy was performed in order to evaluate angiogenesis. During the study, other data such as pain and antibiotic consumption duration were also collected. Wound healing time of pilonidal sinus disease was analyzed using Extended and Stratify Cox model. Data were analyzed using R and STATA software. p |
| Databáze: | OpenAIRE |
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