Comparison of the Effects of Piroxicam and Diclofenac Sodium as Treatments for Primary Dysmenorrhea
| Autor: | Mehpare Camlibel, Aykut Uyanik, Atakan Yilmaz, Bulent Erdur, Mert Ozen |
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| Rok vydání: | 2019 |
| Předmět: |
demography
systolic blood pressure Emergency Medical Services double blind procedure health practitioner 030204 cardiovascular system & hematology dysmenorrhea law.invention 0302 clinical medicine Randomized controlled trial law nonsteroid antiinflammatory agent middle aged Menstrual fluid heart rate Medicine pain comparative study numeric rating scale Adult Anti-Inflammatory Agents Non-Steroidal/therapeutic use Diclofenac/*therapeutic use Double-Blind Method Dysmenorrhea/*drug therapy Female Humans Pain Measurement Piroxicam/*therapeutic use Young Adult emergency health service emergency ward adult Anti-Inflammatory Agents Non-Steroidal analgesia General Medicine Diclofenac Sodium cohort analysis female 030220 oncology & carcinogenesis Anesthesia young adult arterial pressure menstruation Emergency Service Hospital prospective study medicine.drug tramadol analysis of variance prostaglandin F2 Diclofenac Visual analogue scale Piroxicam Article 03 medical and health sciences Emergency service hospital male Dysmenorrhea Clinical Research controlled study gynecological examination human miyadren business.industry clinical effectiveness questionnaire diastolic blood pressure visual analog scale Rescue medication major clinical study oxygen saturation blood pressure monitoring hospital admission randomized controlled trial Mann–Whitney U test pathology intrauterine pressure business body temperature |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.911711 |
| Popis: | BACKGROUND NSAIDs are the most common agents used in dysmenorrhea treatment. They reduce menstrual pain by reducing uterine pressure and PGF2alpha levels in the menstrual fluid. The aim of this study was to compare the effects of piroxicam and diclofenac sodium as treatments for primary dysmenorrhea. MATERIAL AND METHODS The study was conducted using a randomized and double-blind method. Patients with Visual Analogue Scale (VAS) scores greater than 5 were accepted into the study. The patients who were suitable for inclusion were randomized into 2 groups and received either intramuscular piroxicam or diclofenac sodium. The patients' pain levels were measured at baseline and at 15, 30, 45, and 60 min. A VAS of 10 cm, a numeric scale, a verbal scale, and additional symptoms, as well as pain relapse after 24 hours and required analgesics, were recorded. RESULTS The study included 400 patients. Overall, 200 patients (50%) were in the proxicam group, and 200 patients were in the diclofenac sodium group. The average decrease on the VAS after piroxicam or diclofenac administration was measured as 7.9±1.8 cm and 7.9±1.7 cm (median ± standard deviation), respectively. The pain-reducing efficiency of all the treatments was compared using the Mann-Whitney U test (p=0.929). Rescue medication was needed for 25 patients in the proxicam group (p=0.014). Overall, 30 patients in the proxicam group and 41 patients in the proxicam group needed analgesics again in the 24-hour period after treatment (p=0.150). CONCLUSIONS At the end of our study, it was observed that there was no difference in the results of primary dysmenorrhea treatment with 20 mg piroxicam or 75 mg diclofenac sodium. |
| Databáze: | OpenAIRE |
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