Urinary and salivary endocrine measurements to complement Tanner staging in studies of pubertal development
| Autor: | John A. McGrath, Michele Marcus, Carolyn Monteilh, Christie Barker-Cummings, Dale P. Sandler, Juliana W. Meadows, Deborah S. Cousins, Lauren M. Kipling, Mandy Goldberg, Anna Jones, James S. Kesner |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Physiology Pilot Projects Urine Biochemistry Follicle-stimulating hormone chemistry.chemical_compound Families Endocrinology Medicine and Health Sciences Medicine Testosterone Lipid Hormones Longitudinal Studies Sexual Maturation Child Children Multidisciplinary Pubic hair Body Fluids medicine.anatomical_structure Pregnanediol Androgens Female Anatomy Integumentary System Luteinizing hormone Research Article Adolescent Science Endocrine system Humans Sex organ Saliva Breast development Endocrine Physiology business.industry Puberty Repeated measures design Biology and Life Sciences Dehydroepiandrosterone Luteinizing Hormone Hormones chemistry Age Groups People and Places Population Groupings Follicle Stimulating Hormone business human activities Biomarkers Hair |
| Zdroj: | PLoS ONE, Vol 16, Iss 5, p e0251598 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Many studies investigating pubertal development use Tanner staging to assess maturation. Endocrine markers in urine and saliva may provide an objective, sensitive, and non-invasive method for assessing development. Objective Our objective was to examine whether changes in endocrine levels can indicate the onset of pubertal development prior to changes in self-rated Tanner stage. Methods Thirty-five girls and 42 boys aged 7 to 15 years were enrolled in the Growth and Puberty (GAP) study, a longitudinal pilot study conducted from 2007–2009 involving children of women enrolled in the Agricultural Health Study (AHS) in Iowa. We collected saliva and urine samples and assessed pubertal development by self-rated Tanner staging (pubic hair, breast development (girls), genital development (boys)) at three visits over six months. We measured dehydroepiandrosterone (DHEA) in saliva and creatinine-adjusted luteinizing hormone (LH), testosterone, follicle stimulating hormone (FSH), estrone 3-glucuronide (E13G) and pregnanediol 3-glucuronide (Pd3G) concentrations in first morning urine. We evaluated the relationships over time between Tanner stage and each biomarker using repeated measures analysis. Results Among girls still reporting Tanner breast stage 1 at the final visit, FSH levels increased over the 6-month follow-up period and were no longer lower than higher stage girls at the end of follow-up. We observed a similar pattern for testosterone in boys. By visit 3, boys still reporting Tanner genital stage 1 or pubic hair stage 1 had attained DHEA levels that were comparable to those among boys reporting Tanner stages 2 or 3. Conclusions Increasing concentrations of FSH in girls and DHEA and testosterone in boys over a 6-month period revealed the start of the pubertal process prior to changes in self-rated Tanner stage. Repeated, non-invasive endocrine measures may complement the more subjective assessment of physical markers in studies determining pubertal onset. |
| Databáze: | OpenAIRE |
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