Effects of Parkinson’s disease and dopamine on digit span measures of working memory
| Autor: | Laura Smith, Hanna K. Isotalus, Anastasia Bickerton, John P Grogan, Brogan Elizabeth Knight, Elizabeth Coulthard, Alexandra Howat, Lisa Emily Knight, Nerea Irigoras Izagirre |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Levodopa Parkinson's disease Dopamine Dopamine Agents Short-term memory Neuropsychological Tests Affect (psychology) Placebo 050105 experimental psychology short term memory 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation medicine Memory span Humans 0501 psychology and cognitive sciences levodopa Original Investigation Aged Aged 80 and over Pharmacology Recall business.industry Working memory 05 social sciences Dopaminergic Parkinson Disease Middle Aged medicine.disease 3. Good health Parkinson disease Memory Short-Term Mental Recall Parkinson’s disease Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Psychopharmacology Grogan, J, Knight, L E, Smith, L, Irigoras, N I, Howat, A, Knight, B, Bickerton, A, Isotalus, H K & Coulthard, L 2018, ' Effects of Parkinson’s disease and dopamine on digit span measures of working memory ', Psychopharmacology, vol. 235, no. 12, pp. 3443-3450 . https://doi.org/10.1007/s00213-018-5058-6 |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | RationaleParkinson’s disease (PD) impairs working memory (WM) - the ability to maintain items in memory for short periods of time and manipulate them. There is conflicting evidence on the nature of the deficits caused by the disease, and the potential beneficial and detrimental effects of dopaminergic medication on different WM processes.ObjectivesWe hypothesised that PD impairs both maintenance and manipulation of items in WM and dopaminergic medications improve this in PD patients but impair it in healthy older adults.MethodsWe tested 68 PD patients ON and OFF their dopaminergic medication, 83 healthy age-matched controls, and 30 healthy older adults after placebo and levodopa administration. We used the digit span, a WM test with three components (forwards, backwards and sequence recall) that differ in the amount of manipulation required. We analysed the maximum spans and the percentage of lists correctly recalled, which probe capacity of WM and the accuracy of the memory processes within this capacity, respectively.ResultsPD patients had lower WM capacity across all three digit span components, but only showed reduced percentage accuracy on the components requiring manipulation (backwards and sequence spans). Dopaminergic medication did not affect performance in PD patients. In healthy older adults, levodopa did not affect capacity, but did impair accuracy on one of the manipulation components (sequence), without affecting the other (backwards).ConclusionsThis suggests a non-dopaminergic deficit of maintenance capacity and manipulation accuracy in PD patients, and a potential “overdosing” of intact manipulation mechanisms in healthy older adults by levodopa. |
| Databáze: | OpenAIRE |
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