Abnormal cortical activation during an auditory word comprehension task in benign childhood epilepsy with centrotemporal spikes: A magnetoencephalographic study
| Autor: | Yoko Kato, Yoshiko Iwatani, Masako Taniike, Junji Azuma, Ryuzo Hanaie, Junpei Tanigawa, Kuriko Kagitani-Shimono, Junko Matsuzaki |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Adolescent Electroencephalography Audiology Auditory cortex 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine Cognition Medicine Humans Child Cerebral Cortex medicine.diagnostic_test Intelligence quotient business.industry Wechsler Scales Wechsler Adult Intelligence Scale Magnetoencephalography medicine.disease Epilepsy Rolandic Rolandic epilepsy 030104 developmental biology Neurology Acoustic Stimulation Auditory Perception Female Neurology (clinical) business Comprehension 030217 neurology & neurosurgery |
| Zdroj: | Epilepsybehavior : EB. 87 |
| ISSN: | 1525-5069 |
| Popis: | Objective Benign childhood epilepsy with centrotemporal spikes (BECTS), also known as rolandic epilepsy, has recently been reported to be associated with variable degrees of cognitive dysfunction. Many studies reported poor language ability in children with BECTS compared with healthy control children. To elucidate the harmful effects of BECTS on language cognition, we studied the magnetoencephalographic activity elicited by an auditory language comprehension task. Methods The participants (N = 20) included 10 children diagnosed with BECTS (aged 10.8 ± 2.8 years) and 10 age-matched healthy children (control) (aged 10.6 ± 1.6 years). Cognitive function was assessed using general intellectual function and language ability. In patients with BECTS, we reviewed the clinical course and electroencephalogram (EEG) findings. We recorded the cortical responses elicited by an auditory language comprehension task using magnetoencephalography (MEG). We compared those results between groups and analyzed the correlation with cognitive scores and frequency of spikes. Results The full-scale intelligence quotient (FSIQ) by the Wechsler Intelligence Scale for Children—4th edition was significantly reduced in the group with BECTS (96.4 ± 12.3) compared with the control group (110.0 ± 7.4). In half of the group with BECTS, the auditory comprehension score fell below the age-standard level. In the group with BECTS, the cortical activation during the task showed reduced intensity in language-associated areas such as the bilateral primary auditory cortex, left superior and mid-temporal areas, and inferior frontal area compared with those in the control group. In addition, the cortical activation in the left superior temporal area was negatively correlated with spike frequency and positively correlated with FSIQ in the group with BECTS. Conversely, the right inferior frontal and mid-temporal areas had increased the activations in the group with BECTS. From the time frequency analysis, low gamma band event-related desynchronization was reduced in the group with BECTS. Conclusion Epileptic spikes negatively influenced responsiveness to the auditory language comprehension task in the language-associated cortices. These findings suggest that epileptic spikes could have a negative impact on the functional activity in rolandic areas and become a reason to change the functional development of the language network. |
| Databáze: | OpenAIRE |
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