Herbal Substance, Acteoside, Alleviates Intestinal Mucositis in Mice
| Autor: | Cuong D. Tran, Daniel C. Reinke, Alexios L. Skaltsounis, Stamatiki Kritas, Nektarios Aligiannis, Panagiotis Polychronopoulos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Article Subject Ileum Gastroenterology digestive system Jejunum Internal medicine medicine Mucositis lcsh:RC799-869 Hepatology biology business.industry digestive oral and skin physiology Histology Small Intestinal Mucositis medicine.disease 3. Good health medicine.anatomical_structure Myeloperoxidase Immunology Duodenum biology.protein lcsh:Diseases of the digestive system. Gastroenterology Methotrexate business medicine.drug Research Article |
| Zdroj: | Gastroenterology Research and Practice Gastroenterology Research and Practice, Vol 2015 (2015) |
| ISSN: | 1687-630X 1687-6121 |
| Popis: | This study investigated the role of acteoside in the amelioration of mucositis. C57BL/6 mice were gavaged daily with acteoside 600 μg for 5 d prior to induction of mucositis and throughout the experimental period. Mucositis was induced by methotrexate (MTX; 12.5 mg/kg; s.c.). Mice were culled on d 5 and d 11 after MTX. The duodenum, jejunum, and ileum were collected for myeloperoxidase (MPO) activity, metallothionein (MT) levels, and histology. Acteoside reduced histological severity scores by 75, 78, and 88% in the duodenum, jejunum, and ileum, respectively, compared to MTX-controls on d 5. Acteoside reduced crypt depth by 49, 51, and 33% and increased villus height by 19, 38, and 10% in the duodenum, jejunum, and ileum, respectively, compared to MTX-controls on d 5. Acteoside decreased MT by 50% compared to MTX-control mice on d 5. Acteoside decreased MPO by 60% and 30% in the duodenum and jejunum, respectively, compared to MTX-controls on d 5. Acteoside alleviated MTX-induced small intestinal mucositis possibly by preventing inflammation. |
| Databáze: | OpenAIRE |
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