Puerarin mitigates acute liver injury in septic rats by regulating proinflammatory factors and oxidative stress levels

Autor:	Zheng, Jinan, Huang, Qing, Fang, Jingjing
Rok vydání:	2021
Předmět:	Puerarin Proinflammatory factors Oxidative stress Sepsis Acute liver injury Pharmaceutical Science Pharmacology (medical)
Zdroj:	Tropical Journal of Pharmaceutical Research; Vol. 20 No. 11 (2021); 2305-2310
ISSN:	1596-9827 1596-5996
Popis:	Purpose: To determine the protective effect of puerarin against acute liver injury in septic rats, and the mechanism involved.Methods: Eighty-seven Sprague-Dawley (SD) rats were assigned to control, sepsis and puerarin groups (each having 29 rats). Serum levels of NF-kB, TNF-α, IL-1 β, IL-6, ALT and AST were assayed. Liver lesions and levels of NO, SOD, iNOS and malondialdehyde (MDA) were measured using standard procedures.Results: Compared with the control group, the levels of NF-kB, TNF-α, IL-1β, IL-6, AST, ALT, NO, MDA and iNOS significantly increased in the sepsis group, while SOD level decreased significantly. In contrast, there were marked decreases in NF-kB, TNF-α, IL-1β, AST, ALT, NO, MDA and iNOS in puerarin group, relative to the sepsis group, while SOD expression level was significantly increased (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0951004398ae505b1ee1224c06b8b3a https://doi.org/10.4314/tjpr.v20i11.11 Zobrazit plný text záznamu Plný text ve formátu PDF