Angiotensin-converting enzyme inhibition promotes coronary angiogenesis in the failing heart of Dahl salt-sensitive hypertensive rats
| Autor: | Tamayo Murase, Koji Tsuboi, Yosuke Kato, Mayuko Furukawa, Kohzo Nagata, Masaaki Miyachi, Toyoaki Murohara, Miwa Takatsu, Takuya Hattori, Masafumi Ohtake, Hiroki Yazawa, Keiji Takahashi |
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| Rok vydání: | 2011 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Angiogenesis Heart Ventricles Neovascularization Physiologic Angiotensin-Converting Enzyme Inhibitors Muscle hypertrophy chemistry.chemical_compound Fibrosis Internal medicine medicine Perindopril Animals Myocytes Cardiac Antihypertensive Agents Heart Failure Analysis of Variance Rats Inbred Dahl biology business.industry Angiotensin-converting enzyme medicine.disease Rats Vascular endothelial growth factor Disease Models Animal Endocrinology chemistry Heart failure ACE inhibitor Hypertension biology.protein Hypertrophy Left Ventricular Nitric Oxide Synthase Cardiology and Cardiovascular Medicine business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Journal of cardiac failure. 17(12) |
| ISSN: | 1532-8414 |
| Popis: | Background The biologic response to angiotensin-converting enzyme (ACE) inhibitors may be influenced by the local environment. The effect of ACE inhibition on coronary angiogenesis was investigated in a rat model of hypertensive heart failure. Methods and Results Dahl salt-sensitive (DS) rats fed a high-salt diet from 6 weeks of age were treated with a nonantihypertensive dose of the ACE inhibitor perindopril or vehicle from 9 to 18 weeks. Treatment of rats with perindopril attenuated the heart failure as well as cardiac hypertrophy and fibrosis that were manifest in the vehicle-treated animals. Myocardial capillary density as well as the expression of the bradykinin B2 receptor, endothelial nitric oxide synthase, and vascular endothelial growth factor were reduced in the heart of vehicle-treated rats compared with that of nonhypertensive control rats, and all of these changes were attenuated by treatment with perindopril. Conclusions These results indicate that ACE inhibition by perindopril promotes myocardial capillary formation as well as attenuates cardiac remodeling and failure in a manner independent from the antihypertensive effect of the drug in DS hypertensive rats. The beneficial cardiac effects of perindopril were associated with activation of the bradykinin–nitric oxide pathway in the heart. |
| Databáze: | OpenAIRE |
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