Effects of estrogens and progestins on high density lipoproteins
| Autor: | J. Wingerd, D. D. Bradley, Ronald M. Krauss, Frank T. Lindgren, S. Ramcharan |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class media_common.quotation_subject Hyperlipidemias Biochemistry chemistry.chemical_compound High-density lipoprotein Internal medicine medicine Humans Menstrual cycle Triglycerides media_common Aged Triglyceride Organic Chemistry Age Factors nutritional and metabolic diseases Estrogens Cell Biology Middle Aged medicine.disease Menstruation Menopause Endocrinology chemistry Estrogen lipids (amino acids peptides and proteins) Female Norethindrone Luteinizing hormone Lipoproteins HDL Progestin Lipoprotein Contraceptives Oral |
| Zdroj: | Lipids. 14(1) |
| ISSN: | 0024-4201 |
| Popis: | High density lipoprotein (HDL) levels are known to be higher in women than in men, and to increase with estrogen use. To assess the effects of estrogens on HDL subspecies, analytic ultracentrifuge measurements of HDL were compared in 11 menopausal estrogen users and 16 controls. The difference in mean schlieren patterns between the groups showed a significantly higher level of HDL with flotation rate (F 1.20 o )>1.5 (predominantly HDL2) in the users. This was similar to the difference in HDL seen between nonusers of hormones and age-matched males. A previous study had shown that users of combination oral contraceptives had increased levels of HDL with F 1.20 o ≤3.5 (primarily HDL3) suggesting that the estrogen effect on HDL is altered by the presence of added progestin. The progrestin effect was studied here in more detail in two women with type V hyperlipoproteinemia treated with norethindrone acetate. Reduction in serum triglyceride was accompanied by a reduction in HDL, predominantly in the less dense species (HDL2). Among groups of oral contraceptive and noncontraceptive estrogen and progestin users whose HDL-cholesterol levels have been reported recently, there was a direct correlation (r=0.86, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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