Transportation of a commercial premixed intravenous insulin product through a pneumatic tube system
| Autor: | Deborah S. Wagner, Jeff Hurren, Noah Leja, Kirsten Smith |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
Chromatography Chemistry Health Policy Insulin medicine.medical_treatment Sodium Chloride Injection 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Pneumatic tube 03 medical and health sciences 0302 clinical medicine Intravenous insulin medicine Regular insulin Potency Humans Tube (fluid conveyance) Administration Intravenous 0210 nano-technology Insulin products |
| Zdroj: | American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 78(18) |
| ISSN: | 1535-2900 |
| Popis: | Purpose Delivery of insulin products via pneumatic tubes is often avoided in health systems, as agitation may cause insulin proteins to destabilize, resulting in loss of function through denaturation, aggregation, or other processes. The actual loss of potency due to delivery via pneumatic tubes has not been reported for new, ready-to-use insulin products. Methods Samples were drawn from 7 commercial intravenous (IV) bags containing a 100 units/100 mL premixed solution of regular insulin in sodium chloride injection (Myxredlin, Baxter). The bags were then exposed to 7 unique long-distance pneumatic tube routes. The posttransportation bags were visually inspected for evidence of foaming. Samples were drawn from the posttransportation bags and insulin concentrations were analyzed via an enzyme immunoassay and compared to pretransportation concentrations. Results All seven posttransportation insulin samples were within 10% of their respective pretransportation sample. No foaming was observed in any of the Myxredlin bags after transportation through the pneumatic tube system. Conclusion Transporting 100 unit/100 mL Myxredlin i.v. bags through a pneumatic tube system does not result in a clinically significant loss of potency. Therefore, delivery of this drug product via a pneumatic tube system to patient care areas can be considered in daily practice. |
| Databáze: | OpenAIRE |
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