High sPLA2-IIA level is associated with eicosanoid metabolism in patients with bacterial sepsis syndrome

Autor:	Nurul Saadah Ahmad, Khaizurin Tajul Arifin, Toh Leong Tan, Yasmin Anum Mohd Yusof, Wan Zurinah Wan Ngah
Rok vydání:	2020
Předmět:	Bacterial Diseases Male 0301 basic medicine Spla2 iia Bacteremia Pathology and Laboratory Medicine Biochemistry Gastroenterology chemistry.chemical_compound 0302 clinical medicine Heart Rate Medicine and Health Sciences Metabolites Immune Response Multidisciplinary biology Eicosanoid metabolism Neurochemistry Middle Aged Systemic Inflammatory Response Syndrome Lipocalins Intramolecular Oxidoreductases Bacterial sepsis Infectious Diseases Medicine Female lipids (amino acids peptides and proteins) Neurochemicals Research Article Adult medicine.medical_specialty Science Immunology Cardiology Prostaglandin Group II Phospholipases A2 Dinoprostone 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Sepsis Internal medicine medicine Humans In patient Aged Inflammation business.industry Septic shock Biology and Life Sciences 030208 emergency & critical care medicine medicine.disease Metabolism 030104 developmental biology Eicosanoid chemistry Cyclooxygenase 2 Cyclooxygenase 1 biology.protein Eicosanoids sense organs Cyclooxygenase business Biomarkers Neuroscience
Zdroj:	PLoS ONE, Vol 15, Iss 3, p e0230285 (2020) PLoS ONE
ISSN:	1932-6203
DOI:	10.1371/journal.pone.0230285
Popis:	The aim of this study was to determine the association between secretory phospholipase A2 group IIA (sPLA2-IIA) and eicosanoid pathway metabolites in patients with bacterial sepsis syndrome (BSS). Levels of sPLA2-IIA, eicosanoids prostaglandin (PG)E2, PGD synthase were quantified in the sera from patients confirmed to have bacterial sepsis (BS; N = 45), bacterial severe sepsis/septic shock (BSS/SS; N = 35) and healthy subjects (N = 45). Cyclooxygenase (COX)-1 and COX-2 activities were analyzed from cell lysate. Serum levels of sPLA2-IIA, PGE2, and PGDS increased significantly in patients with BS and BSS/SS compared to healthy subjects (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08fb2978ba9ddd20836744e1c6d6aba https://doi.org/10.1371/journal.pone.0230285 Zobrazit plný text záznamu