The interaction between gut microbiota and flavonoid extract from Smilax glabra Roxb. and its potent alleviation of fatty liver
| Autor: | Ziyan Qi, Ya-Dong Cui, Faiz Ur Rehman, Ling Yi, Yali Li, Jianhua Yang, Jiangyun Liu, Lei Zhao, Jingjing Li, Jian Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_treatment Flavonoid Smilax glabra Gut flora Diet High-Fat 01 natural sciences Rats Sprague-Dawley 03 medical and health sciences chemistry.chemical_compound Feces Non-alcoholic Fatty Liver Disease medicine Animals Humans 030304 developmental biology chemistry.chemical_classification Flavonoids 0303 health sciences biology Bacteria Chemistry Prebiotic 010401 analytical chemistry Fatty liver General Medicine biology.organism_classification medicine.disease Fatty Acids Volatile 0104 chemical sciences Gastrointestinal Microbiome Rats Prebiotics Biochemistry Smilax Astilbin Steatosis Dysbiosis Food Science Drugs Chinese Herbal |
| Zdroj: | Foodfunction. 12(17) |
| ISSN: | 2042-650X |
| Popis: | Fatty liver is associated with intestinal microbiota dysbiosis and low-grade chronic inflammation. Herein we report the interaction of the flavonoid extract from Smilax glabra Roxb. (FSGR) with gut microbiota. Then, FSGR's function of modulating microbiota in a rat model of high-fat diet (HFD) induced fatty liver has been explored. These investigations indicated that the main compound in FSGR, such as astilbin and its isomers, could be metabolized to aglycone, while further splitting resulted in some phenolic acid compounds through a redox reaction. The data obtained clearly showed that FSGR not only alleviated the steatosis degree of liver cells and modulated the contents of short chain fatty acids (SCFAs) in the intestinal tract, but also reversed gut dysbiosis induced by HFD as prognosticated by the decreased ratio of Firmicutes/Bacteroidetes (F/B) and altered gene expression. The results demonstrated that FSGR probably could be used as a prebiotic agent to impede gut dysbiosis and fatty liver-related metabolic disorders. |
| Databáze: | OpenAIRE |
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