In vivo quantitative microimaging of rat spinal cord at 7T
| Autor: | Florence Franconi, Pierre Jallet, L. Marescaux, J.-J. Le Jeune, Laurent Lemaire |
|---|---|
| Přispěvatelé: | Micro et Nanomédecines Translationnelles (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2000 |
| Předmět: |
Relaxometry
Time Factors Cord MESH: Rats [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging MESH: Rats Sprague-Dawley MESH: Cervical Vertebrae MESH: Magnetic Resonance Imaging Diffusion Rats Sprague-Dawley MESH: Spinal Cord Animal model Nuclear magnetic resonance Cerebrospinal fluid [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication In vivo MESH: Analysis of Variance medicine Animals Effective diffusion coefficient MESH: Animals Radiology Nuclear Medicine and imaging Magnetization transfer Analysis of Variance Chemistry MESH: Time Factors MESH: Diffusion Spinal cord Magnetic Resonance Imaging Rats medicine.anatomical_structure Spinal Cord Cervical Vertebrae Female MESH: Female |
| Zdroj: | Magnetic Resonance in Medicine Magnetic Resonance in Medicine, Wiley, 2000, 44 (6), pp.893-898. ⟨10.1002/1522-2594(200012)44:63.0.co;2-g⟩ ResearcherID |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/1522-2594(200012)44:6<893::aid-mrm10>3.0.co;2-g |
| Popis: | International audience; In vivo T(2), ADC, and MT properties of the GM and WM of the rat spinal cord were measured at 7T in the cervical region. The GM T(2), T(2GM) = 43.2 +/- 1.0 msec is significantly reduced compared to the WM T(2), T(2WM) = 57.0 +/- 1.6 msec. Diffusion is anisotropic for both GM and WM, with a larger ADC value along the cord axis (ADC(GM//) = 1.05 +/- 0.09 10(-9) m(2)sec(-1) and ADC(WM//) = 1.85 +/- 0.18 10(-9) m(2)sec(-1)) than perpendicular to this plane (ADC(GM)( perpendicular) approximately 0.50 * 10(-9) m(2)sec(-1) and ADC(WM)( perpendicular) approximately 0.18 * 10(-9) m(2)sec(-1)). The MT properties do not significantly differ between the WM and the GM, but allow one to distinguish the thin CSF layer from the WM. DWI with the sensitizing gradient perpendicular to the cord axis leads to the best contrast between GM and WM in the cervical region. |
| Databáze: | OpenAIRE |
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