Expression of activation markers CD23 and CD69 in B-cell non-Hodgkin's lymphoma
| Autor: | Göran Roos, Jack Lindh, E. Grönlund, Eva Löfvenberg, Martin Erlanson |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Antigens Differentiation T-Lymphocyte Male Lymphoma B-Cell Lymphocyte Biology Flow cytometry Antigen Antigens CD immune system diseases hemic and lymphatic diseases medicine Humans Lectins C-Type B cell Aged Aged 80 and over CD20 medicine.diagnostic_test Receptors IgE CD23 hemic and immune systems Hematology General Medicine Middle Aged medicine.disease Survival Analysis Non-Hodgkin's lymphoma Lymphoma medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Immunology biology.protein Female Immunoglobulin Light Chains Lymph Nodes Biomarkers |
| Zdroj: | European Journal of Haematology. 60:125-132 |
| ISSN: | 1600-0609 0902-4441 |
| Popis: | The activation associated proteins CD23 and CD69 are expressed on cells of different lineages upon mitogenic stimulation. CD23 is a well characterized multifunctional protein in lymphocyte development recognized as a diagnostic marker for chronic lymphocytic leukaemia. CD69 is one of the earliest markers expressed after activation of T cells, but its function is unclear. The aim of this study was to investigate the expression of these antigens in B-cell non-Hodgkin's lymphomas (NHL) in relation to clinical behaviour. Ninety samples from 84 patients with NHL of B cell type were studied for the expression of CD23 and CD69 in CD20+ B cells by flow cytometric dual parameter analysis. In individual lymphomas the CD23 and CD69 antigens showed an "on or off" pattern with most or very few cells positive for each antigen. The CD23 antigen was expressed in 23 of 53 (43%) indolent lymphomas and in 2 of 37 (5%) aggressive cases. Most indolent lymphomas (81%) and about half the aggressive cases (53%) expressed the CD69 antigen. Thus, both markers were associated with indolent type. CD23 expression correlated with chronic lymphocytic leukaemia subtype and CD69 expression with male gender, advanced stage, newly diagnosed lymphoma and shorter survival. |
| Databáze: | OpenAIRE |
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