The discovery and mechanism of sweet taste enhancers
| Autor: | Catherine Tachdjian, Xiaodong Li, Guy Servant |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
venus flytrap domain
Taste Sucralose Sucrose QH301-705.5 Mechanism (biology) digestive oral and skin physiology food and beverages umami taste receptor General Medicine Umami g-protein-coupled receptor Artificial Sweetener General Biochemistry Genetics and Molecular Biology Cellular and Molecular Neuroscience chemistry.chemical_compound stomatognathic system chemistry Biochemistry positive allosteric modulator sweet taste enhancer sweet taste receptor Biology (General) Sugar Enhancer |
| Zdroj: | Biomolecular Concepts, Vol 2, Iss 4, Pp 327-332 (2011) |
| ISSN: | 1868-503X 1868-5021 |
| Popis: | Excess sugar intake posts several health problems. Artificial sweeteners have been used for years to reduce dietary sugar content, but they are not ideal substitutes for sugar owing to their off-taste. A new strategy focused on allosteric modulation of the sweet taste receptor led to identification of sweet taste ‘enhancers’ for the first time. The enhancer molecules do not taste sweet, but greatly potentiate the sweet taste of sucrose and sucralose selectively. Following a similar mechanism as the natural umami taste enhancers, the sweet enhancer molecules cooperatively bind with the sweeteners to the Venus flytrap domain of the human sweet taste receptor and stabilize the active conformation. Now that the approach has proven successful, enhancers for other sweeteners and details of the molecular mechanism for the enhancement are being actively pursued. |
| Databáze: | OpenAIRE |
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