Sessile serrated polyp prevalence determined by a colonoscopist with a high lesion detection rate and an experienced pathologist
| Autor: | Khaled Abdeljawad, Dale C. Snover, Oscar W. Cummings, Douglas K. Rex, Charles J. Kahi, Krishna C. Vemulapalli |
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| Rok vydání: | 2013 |
| Předmět: |
musculoskeletal diseases
Adenoma Male medicine.medical_specialty Pathology Indiana Colorectal cancer Population Colonoscopy Colonic Polyps Gastroenterology Asymptomatic stomatognathic system Internal medicine medicine Prevalence Humans Radiology Nuclear Medicine and imaging education Early Detection of Cancer Aged Retrospective Studies Aged 80 and over education.field_of_study medicine.diagnostic_test business.industry Sigmoid colon Middle Aged medicine.disease eye diseases stomatognathic diseases medicine.anatomical_structure Hyperplastic Polyp Dysplasia Colonic Neoplasms Female medicine.symptom business Sessile serrated adenoma |
| Zdroj: | Gastrointestinal endoscopy. 81(3) |
| ISSN: | 1097-6779 |
| Popis: | Background The prevalence of sessile serrated adenomas and/or polyps (SSA/Ps) is uncertain. Objective To determine the prevalence of SSA/Ps and SSA/Ps with cytologic dysplasia (SSA/P-CD) by using a colonoscopist with a high lesion detection rate and an expert in serrated lesion pathology. Design Retrospective screening colonoscopy study. Setting Academic endoscopy unit. Patients A total of 1910 average risk, asymptomatic patients aged ≥50 years underwent screening colonoscopy between August 2005 and April 2012 by a single colonoscopist with a high lesion detection rate. Interventions Slides of all lesions in the serrated class proximal to the sigmoid colon and all rectal and sigmoid colon serrated lesions >5 mm in size were reviewed by an experienced GI pathologist. Main Outcome Measurements Prevalence of SSA/Ps, defined as the proportion of patients with ≥1 SSA/P. Results There were 1910 patients, of whom 389 had 656 lesions in the serrated class. Review by the experienced GI pathologist determined a prevalence of SSA/Ps without cytologic dysplasia of 7.4% and SSA/Ps-CD of 0.6% (total SSA/P prevalence 8.1%). SSA/Ps and SSA/Ps-CD comprised 5.6% and 0.3%, respectively, of all resected polyps. The mean size of SSA/Ps was 7.13 mm (standard deviation [SD] 4.66), and 51 of 77 (66.2%) polyps ≥10 mm in the serrated class were SSA/Ps. Limitations Retrospective design. Conclusion A colonoscopist with a high lesion detection rate and an experienced pathologist identified a high prevalence (8.1%) of SSA/Ps in a screening population. SSA/Ps are more common than previously believed. |
| Databáze: | OpenAIRE |
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