Successful treatment of fungal endophthalmitis using intravitreal caspofungin

Autor: Dorin Chiselita, C Danielescu, Alina Cantemir
Rok vydání: 2017
Předmět:
medicine.medical_specialty
Antifungal Agents
Visual Acuity
Drug resistance
Gastroenterology
Echinocandins
Lipopeptides
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Pharmacotherapy
Endophthalmitis
lcsh:Ophthalmology
Caspofungin
Vitrectomy
Internal medicine
Amphotericin B
Phacoemulsification/adverse effects
polycyclic compounds
Humans
Medicine
skin and connective tissue diseases
Candida
Voriconazole
Phacoemulsification
business.industry
Reproducibility of Results
General Medicine
Middle Aged
Eye infection
bacterial infections and mycoses
medicine.disease
Ophthalmology
Treatment Outcome
chemistry
lcsh:RE1-994
Intravitreal Injections
Saccharomycetales
030221 ophthalmology & optometry
Female
business
Eye Infections
Fungal
030217 neurology & neurosurgery
Fluconazole
medicine.drug
Zdroj: Arquivos Brasileiros de Oftalmologia, Vol 80, Iss 3, Pp 196-198
ISSN: 0004-2749
DOI: 10.5935/0004-2749.20170048
Popis: Fungal endophthalmitis is a rare condition often associated with poor prognosis. We present a case of postoperative acute fungal endophthalmitis caused by the yeast-like fungus Stephanoascus ciferrii (Candida ciferrii). The fungus was resistant to fluconazole, voriconazole, and amphotericin B but susceptible to caspofungin. Because the degree of vitreal penetration of caspofungin after its intravenous administration is unclear, we performed multiple intravitreal injections, first with 50 µg/0.1 ml and then with 250 µg/0.1 ml caspofungin. Despite the recurrence of symptoms, intravitreal injection of caspofungin finally abolished the inflammation and achieved ambulatory vision that persisted until 1 year of follow-up. To our knowledge, this is the first report of S. ciferrii endophthalmitis and its successful treatment with intravitreal caspofungin.
Databáze: OpenAIRE
Externí odkaz: