Scary symptoms? Functional magnetic resonance imaging evidence for symptom interpretation bias in pathological health anxiety

Autor: Daniela Mier, Carsten Diener, Zhimin Yan, Michael Witthöft, Josef Bailer
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Emotions
Posterior parietal cortex
Audiology
Amygdala
Developmental psychology
03 medical and health sciences
Executive Function
0302 clinical medicine
ddc:150
medicine
Humans
Pharmacology (medical)
Cerebrum
Biological Psychiatry
Neural correlates of consciousness
medicine.diagnostic_test
Functional Neuroimaging
Implicit-association test
Cognition
General Medicine
Middle Aged
Anxiety Disorders
Magnetic Resonance Imaging
Cognitive bias
030227 psychiatry
Hypochondriasis
Pathological health anxiety
Implicit association test
Functional magnetic resonance imaging
Cognitive control
Emotional response
Psychiatry and Mental health
medicine.anatomical_structure
Anxiety
Female
medicine.symptom
Functional magnetic resonance imaging
Psychology
030217 neurology & neurosurgery
Zdroj: European archives of psychiatry and clinical neuroscience. 269(2)
ISSN: 1433-8491
Popis: Patients with pathological health anxiety (PHA) tend to automatically interpret bodily sensations as sign of a severe illness. To elucidate the neural correlates of this cognitive bias, we applied an functional magnetic resonance imaging adaption of a body-symptom implicit association test with symptom words in patients with PHA (n = 32) in comparison to patients with depression (n = 29) and healthy participants (n = 35). On the behavioral level, patients with PHA did not significantly differ from the control groups. However, on the neural-level patients with PHA in comparison to the control groups showed hyperactivation independent of condition in bilateral amygdala, right parietal lobe, and left nucleus accumbens. Moreover, patients with PHA, again in comparison to the control groups, showed hyperactivation in bilateral posterior parietal cortex and left dorsolateral prefrontal cortex during incongruent (i.e., harmless) versus congruent (i.e., dangerous) categorizations of body symptoms. Thus, body-symptom cues seem to trigger hyperactivity in salience and emotion processing brain regions in PHA. In addition, hyperactivity in brain regions involved in cognitive control and conflict resolution during incongruent categorization emphasizes enhanced neural effort to cope with negative implicit associations to body-symptom-related information in PHA. These results suggest increased neural responding in key structures for the processing of both emotional and cognitive aspects of body-symptom information in PHA, reflecting potential neural correlates of a negative somatic symptom interpretation bias. published
Databáze: OpenAIRE
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