Miconazole therapy for fungal meningitis
| Autor: | Guy D. Campbell, Jan G. Grendahl, James P. Sung |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Drug
Fungal meningitis Adult Male medicine.medical_specialty Miconazole media_common.quotation_subject Intrathecal Gastroenterology Histoplasmosis Arts and Humanities (miscellaneous) Amphotericin B Internal medicine Cisterna Magna medicine Humans In patient Meningitis Injections Spinal media_common Aged Cerebral Hemorrhage Coccidioidomycosis Low toxicity business.industry Imidazoles Cryptococcosis Middle Aged medicine.disease Arachnoiditis Mycoses Anesthesia Injections Intravenous Neurology (clinical) business medicine.drug |
| Zdroj: | Archives of neurology. 35(7) |
| ISSN: | 0003-9942 |
| Popis: | Eight patients with fungal meningitis (5 with the coccidioidal type, 2 with cryptococcal, and 1 with histoplasmosis) were treated with intravenous (IV) and intrathecal (IT) miconazole after previous therapy with amphotericin B proved unsuccessful. Miconazole was well tolerated with both IV and IT administration. The CSF concentration of miconazole one hour after an IV infusion of 800 mg was 0.1 to 0.3 microgram/ml. When 20 mg of miconazole was administered intrathecally via lumbar injection in patients with coccidioidal meningitis, 6.5, 2.4, 0.77, and 0.24 microgram/ml, respectively, was found in the CSF at the cisternal level at 12, 24, 48, and 72 hours, respectively. Miconazole is apparently an effective fungistatic drug of low toxicity and is a potentially useful agent in the treatment of systemic mycoses and fungal meningitis, in particular. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|