Intense light as anticoagulant therapy in humans
| Autor: | Nathan Clendenen, Pavel Davizon-Castillo, Sydney Shuff, Yoshimasa Oyama, Tobias Eckle |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Light therapy
Male Proteomics Critical Care and Emergency Medicine Light Platelet Aggregation Physiology medicine.medical_treatment Myocardial Ischemia Vascular Medicine Biochemistry Mice Megakaryocyte Animal Cells Ischemia Blood plasma Medicine and Health Sciences Medicine Platelet Trauma Medicine Multidisciplinary Period Circadian Proteins Animal Models Hematology Body Fluids Circadian Rhythms Circadian Oscillators medicine.anatomical_structure Blood Coagulation Experimental Organism Systems Reperfusion Injury Anatomy Cellular Types Research Article Blood Platelets Platelets medicine.medical_specialty endocrine system Science Myocardial Reperfusion Injury Mouse Models Research and Analysis Methods Blood Plasma Model Organisms Internal medicine Animals Humans Circadian rhythm Blood Coagulation Blood Cells business.industry Biology and Life Sciences Cell Biology Phototherapy medicine.disease Endocrinology Animal Studies business Reperfusion injury Chronobiology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 15, Iss 12, p e0244792 (2020) |
| ISSN: | 1932-6203 |
| Popis: | Blood coagulation is central to myocardial ischemia and reperfusion (IR) injury. Studies on the light elicited circadian rhythm protein Period 2 (PER2) using whole bodyPer2-/-mice found deficient platelet function and reduced clotting which would be expected to protect from myocardial IR-injury. In contrast, intense light induction of PER2 protected from myocardial IR-injury whilePer2deficiency was detrimental. Based on these conflicting data, we sought to evaluate the role of platelet specific PER2 in coagulation and myocardial ischemia and reperfusion injury. We demonstrated that platelets from mice with tissue-specific deletion ofPer2in the megakaryocyte lineage (Per2loxP/loxP-PF4-CRE) significantly clot faster than platelets from control mice. We further found increases in infarct sizes or plasma troponin levels inPer2loxP/loxP-PF4-CRE mice when compared to controls. As intense light increases PER2 protein in human tissues, we also performed translational studies and tested the effects of intense light therapy on coagulation in healthy human subjects. Our human studies revealed that intense light therapy repressed procoagulant pathways in human plasma samples and significantly reduced the clot rate. Based on these results we conclude that intense light elicited PER2 has an inhibitory function on platelet aggregation in mice. Further, we suggest intense light as a novel therapy to prevent or treat clotting in a clinical setting. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |