Role of ecdysone 20-monooxygenase in regulation of 20-hydroxyecdysone levels by juvenile hormone and biogenic amines in Drosophila
| Autor: | I. Y. Rauschenbach, N. A. Chentsova, N. V. Adonyeva, N. E. Gruntenko, A. A. Alekseev |
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| Rok vydání: | 2007 |
| Předmět: |
Biogenic Amines
medicine.medical_specialty Physiology Dopamine Ecdysterone 20-Hydroxyecdysone Biochemistry Levodopa chemistry.chemical_compound Endocrinology Internal medicine Biogenic amine medicine Animals Drosophila Proteins Octopamine Ecology Evolution Behavior and Systematics chemistry.chemical_classification biology Age Factors Octopamine (drug) biology.organism_classification Dihydroxyphenylalanine Juvenile Hormones Drosophila virilis Kinetics Drosophila melanogaster chemistry Steroid Hydroxylases Juvenile hormone Female Animal Science and Zoology Aryl Hydrocarbon Hydroxylases Ecdysone |
| Zdroj: | Journal of Comparative Physiology B. 178:27-32 |
| ISSN: | 1432-136X 0174-1578 |
| DOI: | 10.1007/s00360-007-0196-x |
| Popis: | The effects of increased levels of dopamine (feeding flies with dopamine precursor, L: -dihydroxyphenylalanine) and octopamine (feeding flies with octopamine) on ecdysone 20-monooxygenase activity in young (2 days old) wild type females (the strain wt) of Drosophila virilis have been studied. L: -dihydroxyphenylalanine and octopamine feeding increases ecdysone 20-monooxygenase activity by a factor of 1.6 and 1.7, respectively. Ecdysone 20-monooxygenase activity in the young (1 day old) octopamineless females of the strain Tbetah ( nM18 ), in females of the strain P845 (precursor of Tbetah ( nM18 ) strain) and in wild type females (Canton S) of Drosophila melanogaster have been measured. The absence of octopamine leads to a considerable decrease in the enzyme activity. We have also studied the effects of juvenile hormone application on ecdysone 20-monooxygenase activity in 2-day-old wt females of D. virilis and demonstrated that an increase in juvenile hormone titre leads to an increase in the enzyme activity. We discuss the supposition that ecdysone 20-monooxygenase occupies a key position in the regulation of 20-hydroxyecdysone titre under the conditions that lead to changes in juvenile hormone titre and biogenic amine levels. |
| Databáze: | OpenAIRE |
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