The effects of Diet and corticosteroid-induced immune suppression during infection by Haemonchus contortus in lambs
| Autor: | José Henrique das Neves, Nadino Carvalho, Helder Louvandini, Carina Nazato, Alessandro Francisco Talamini do Amarante |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.drug_class Sheep Diseases Rumen Basal (phylogenetics) Animal science parasitic diseases medicine Animals Dry matter Methylprednisolone Hemisuccinate Parasite Egg Count Nutrition Immunosuppression Therapy chemistry.chemical_classification Sheep General Veterinary biology Immunity Fatty acid General Medicine biology.organism_classification veterinary(all) Diet chemistry Immunoglobulin G Worm control Immunology Hay Corticosteroid Female Haemonchus Parasitology Haemonchiasis Glucocorticoid medicine.drug Haemonchus contortus |
| Zdroj: | Veterinary Parasitology. 214:289-294 |
| ISSN: | 0304-4017 |
| DOI: | 10.1016/j.vetpar.2015.09.012 |
| Popis: | To evaluate the effects of Diet and corticosteroid-induced immune suppression during infection by Haemonchus contortus, 28 lambs were allocated to one of four groups treated as follows: Group Basal Diet – Normal; Group Basal Diet – Immune-Suppressed; Group Supplemented Diet – Normal; and Group Supplemented Diet – Immune-Suppressed. The Basal Diet contained Cynodon dactylon (cv. coast cross) hay with 82g crude protein (CP)/kg dry matter (DM), which was provided to the lambs in all groups ad libitum. In addition, animals on the Supplemented Diet received daily a commercial concentrate containing 171g CP/kg DM, which was offered in an amount corresponding to 3% of the animal's live weight. The Immune-Suppressed groups received treatments with the glucocorticoid methylprednisolone sodium succinate (1.33mg/kg of body weight), administered weekly. All lambs received a single infection with 4000 H. contortus infective larvae (L3) and were euthanised 28 days post-infection. Differences in pH and in the short-chain fatty acid (SCFA) concentrations occurred in rumen as a result of the distinct Diets offered to lambs. Such changes, however, did not have any apparent effect on larvae exsheathment and/or larvae survival inside the rumen, with all groups presenting similar worm burdens. However, animals on the Supplemented Diet presented reductions in worm growth and faecal egg counts. There was a significant effect of the Diet on the IgG levels against total antigens of H. contortus L3 from 7 to 27 days post-infection, with supplemented animals showing higher overall mean values (P |
| Databáze: | OpenAIRE |
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