Competitive binding of antagonistic peptides fine-tunes stomatal patterning
| Autor: | Soon-Ki Han, Ya Chen Lisa Lin, Julian Avila, Michal Maes, Marketa Hnilova, Jin Suk Lee, Aarthi Putarjunan, Keiko U. Torii |
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| Rok vydání: | 2015 |
| Předmět: |
MAP Kinase Signaling System
Arabidopsis Receptors Cell Surface Peptide Protein Serine-Threonine Kinases Binding Competitive DNA-binding protein Article Enzyme activator Phosphorylation Receptor Transcription factor chemistry.chemical_classification Multidisciplinary biology Arabidopsis Proteins Kinase fungi biology.organism_classification Hypocotyl Cell biology Enzyme Activation DNA-Binding Proteins chemistry Biochemistry Seedlings Plant Stomata Mitogen-Activated Protein Kinases Transcription Factors |
| Zdroj: | Nature |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/nature14561 |
| Popis: | During development, cells interpret complex and often conflicting signals to make optimal decisions. Plant stomata, the cellular interface between a plant and the atmosphere, develop according to positional cues, which include a family of secreted peptides called epidermal patterning factors (EPFs). How these signalling peptides orchestrate pattern formation at a molecular level remains unclear. Here we report in Arabidopsis that Stomagen (also called EPF-LIKE9) peptide, which promotes stomatal development, requires ERECTA (ER)-family receptor kinases and interferes with the inhibition of stomatal development by the EPIDERMAL PATTERNING FACTOR 2 (EPF2)-ER module. Both EPF2 and Stomagen directly bind to ER and its co-receptor TOO MANY MOUTHS. Stomagen peptide competitively replaced EPF2 binding to ER. Furthermore, application of EPF2, but not Stomagen, elicited rapid phosphorylation of downstream signalling components in vivo. Our findings demonstrate how a plant receptor agonist and antagonist define inhibitory and inductive cues to fine-tune tissue patterning on the plant epidermis. |
| Databáze: | OpenAIRE |
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