Association between Helicobacter pylori infection and nonalcoholic fatty liver disease: A systematic review and meta‐analysis of observational studies
| Autor: | Kai Wang, Yao-Wei Ai, Huai-Jie Yang, Ben-Gang Zhou, Peng Guo, Wei Xu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Risk
medicine.medical_specialty Funnel plot Subgroup analysis Helicobacter Infections Cohort Studies 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Internal medicine Nonalcoholic fatty liver disease Odds Ratio medicine Humans Prospective cohort study Helicobacter pylori business.industry Confounding Gastroenterology General Medicine Odds ratio Publication bias medicine.disease Cross-Sectional Studies Infectious Diseases Case-Control Studies 030220 oncology & carcinogenesis Meta-analysis 030211 gastroenterology & hepatology business |
| Zdroj: | Helicobacter. 24:e12576 |
| ISSN: | 1523-5378 1083-4389 |
| DOI: | 10.1111/hel.12576 |
| Popis: | BACKGROUND The association between Helicobacter pylori (H. pylori) infection and nonalcoholic fatty liver disease (NAFLD) has been shown in many observational studies, but these conclusions remain controversial. Hence, we performed a meta-analysis to elucidate the association. METHODS A comprehensive search was conducted on relevant studies published from inception to December 31, 2018, in PubMed, EMBASE, and Web of Science databases. Odds ratio (OR) with 95% confidence interval (95% CI) were pooled by random-effect model, generic inverse variance method. Subgroup and sensitivity analyses were also done. Publication bias was estimated by the funnel plot, Begg's test, and Egger's test. RESULTS Fifteen studies (eleven cross-sectional, two case-control, and two cohort studies) were included in this meta-analysis. The pooled OR of NAFLD in patients with H. pylori infection was 1.19 (95% CI: 1.11-1.29, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|