Genetics and functional genomics of multiple sclerosis

Autor:	Woori, Kim, Nikolaos A, Patsopoulos
Rok vydání:	2022
Předmět:	Multiple Sclerosis Immunology Humans Immunology and Allergy Genetic Predisposition to Disease Neurodegenerative Diseases Genomics Genome-Wide Association Study
Zdroj:	Seminars in Immunopathology. 44:63-79
ISSN:	1863-2300 1863-2297
Popis:	Multiple sclerosis (MS) is an inflammatory neurodegenerative disease with genetic predisposition. Over the last decade, genome-wide association studies with increasing sample size led to the discovery of robustly associated genetic variants at an exponential rate. More than 200 genetic loci have been associated with MS susceptibility and almost half of its heritability can be accounted for. However, many challenges and unknowns remain. Definitive studies of disease progression and endophenotypes are yet to be performed, whereas the majority of the identified MS variants are not yet functionally characterized. Despite these shortcomings, the unraveling of MS genetics has opened up a new chapter on our understanding MS causal mechanisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a081ec01db0abe5bd5807f2e725a2196 https://doi.org/10.1007/s00281-021-00907-3 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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