Estimation of Canine Leishmania Infection Prevalence in Six Cities of the Algerian Littoral Zone Using a Bayesian Approach
| Autor: | Rachid Bouguedour, Abdelmalek Bouhbal, Dirk Berkvens, Karim Boughalem, Amel Adel, Niko Speybroeck, Claude Saegerman, Mouloud Djerbal, Abdelkrim Soukehal, Emmanuel Abatih |
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| Přispěvatelé: | UCL - SSS/IRSS - Institut de recherche santé et société |
| Rok vydání: | 2015 |
| Předmět: |
Veterinary medicine
Prevalence lcsh:Medicine Models Biological Dogs Direct agglutination test parasitic diseases Confidence Intervals medicine Animals Dog Diseases Cities Fluorescent Antibody Technique Indirect lcsh:Science Leishmaniasis Direct fluorescent antibody Ecosystem Multidisciplinary Geography biology Incidence (epidemiology) lcsh:R Bayes Theorem Gold standard (test) medicine.disease biology.organism_classification Visceral leishmaniasis Fluorescent Antibody Technique Direct Algeria lcsh:Q Leishmania infantum Research Article |
| Zdroj: | PLoS ONE, Vol 10, Iss 3, p e0117313 (2015) PLoS ONE PLoS One, Vol. 10, p. e0117313 (2015) |
| ISSN: | 1932-6203 |
| Popis: | A large-scale study on canine Leishmania infection (CanL) was conducted in six localities along a west-east transect in the Algerian littoral zone (Tlemcen, Mostaganem, Tipaza, Boumerdes, Bejaia, Jijel) and covering two sampling periods. In total 2,184 dogs were tested with an indirect fluorescent antibody test (IFAT) and a direct agglutination test (DAT). Combined multiple-testing and several statistical methods were compared to estimate the CanL true prevalence and tests characteristics (sensitivity and specificity). The Bayesian full model showed the best fit and yielded prevalence estimates between 11% (Mostaganem, first period) and 38% (Bejaia, second period). Sensitivity of IFAT varied (in function of locality) between 86% and 88% while its specificity varied between 65% and 87%. DAT was less sensitive than IFAT but showed a higher specificity (between 80% and 95% in function of locality or/and season). A general increasing trend of the CanL prevalence was noted from west to east. A concordance between the present results and the incidence of human cases of visceral leishmaniasis was observed, where also a maximum was recorded for Bejaia. The results of the present study highlight the dangers when using IFAT as a gold standard. |
| Databáze: | OpenAIRE |
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