Permeability of Isolated Rat Heart Sarcosomes

Autor:	K. W. Cleland
Rok vydání:	1952
Předmět:	Isolated mitochondria Multidisciplinary Myocardium Cardiac muscle chemistry.chemical_element Rat heart Calcium Mitochondrion Permeability Mitochondria Muscle medicine.anatomical_structure chemistry Permeability (electromagnetism) medicine Biophysics Swelling medicine.symptom
Zdroj:	Nature. 170:497-499
ISSN:	1476-4687 0028-0836
DOI:	10.1038/170497a0
Popis:	THE study of the permeability of mitochondria, to which the sarcosomes of cardiac muscle are closely related, has depended on indirect, mostly biochemical, methods1,2. One of the difficulties in any other approach has been the relatively great (and obviously abnormal) permeability of isolated mitochondria or sarcosomes to most ions at room temperature, which results in swelling and other morphological changes. With the discovery that Ca++ ions are intimately related to this abnormal permeability of sarcosomes and that the calcium-chelating agent versene, by removing calcium from the granules, greatly increases, their stability at room temperature3, the problem of sarcosome permeability has become more accessible to attack by other methods.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0810211c80731494f1ddf6bc0e5d90b https://doi.org/10.1038/170497a0 Zobrazit plný text záznamu