Obesity and COVID-19: what makes obese host so vulnerable?

Autor: Saeed Al Mahri, Rafia Aziz, Sameer Mohammad, Abderrezak Bouchama, Altaf Khan, Tanvir Khatlani, Esraa Haji, Shuja Shafi Malik
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Immunity & Ageing, Vol 18, Iss 1, Pp 1-10 (2021)
Immunity & Ageing : I & A
ISSN: 1742-4933
Popis: The disease (COVID-19) novel coronavirus pandemic has so far infected millions resulting in the death of over a million people as of Oct 2020. More than 90% of those infected with COVID-19 show mild or no symptoms but the rest of the infected cases show severe symptoms resulting in significant mortality. Age has emerged as a major factor to predict the severity of the disease and mortality rates are significantly higher in elderly patients. Besides, patients with underlying conditions like Type 2 diabetes, cardiovascular diseases, hypertension, and cancer have an increased risk of severe disease and death due to COVID-19 infection. Obesity has emerged as a novel risk factor for hospitalization and death due to COVID-19. Several independent studies have observed that people with obesity are at a greater risk of severe disease and death due to COVID-19. Here we review the published data related to obesity and overweight to assess the possible risk and outcome in Covid-19 patients based on their body weight. Besides, we explore how the obese host provides a unique microenvironment for disease pathogenesis, resulting in increased severity of the disease and poor outcome.
Databáze: OpenAIRE
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