| Autor: |
Shaofan Weng, Hyun Ho Choi, Douglas Webb, Ismael Samudio, Nibal Rizk, John D. Hazle, Enrique Fuentes-Mattei, Mouhammed Amir Habra, Lajos Pusztai, Sai Ching J. Yeung, Stephen Skerl, Wei Tse Yang, Marc S. Ramirez, Jaehyuk Lee, Yaling Huang, Huamin Wang, Xin Lin, Ping Chieh Chou, Yu Ye Wen, James A. Bankson, Chun Hui Su, Dianna D. Cody, Charles V. Kingsley, Kenneth Parreno, Marzenna Blonska, Yun Wu, Guermarie Velazquez-Torres, Andrew Elliott, Jian Chen, Colin Carlock, Jorge Delacerda, Christine Y. Shiang, Hua Wang, Mong Hong Lee, Thuy M. Vu, Brian C. Grabiner, Lei Li, Christopher Gully, Xuefeng Xia, Yiping Shao, Liem Phan, Ji-Hyun Shin, Zhongguo Zhou, Yun Chih Hsieh, Aijun Zhang, Chieh Tseng, Yongxing Wang, Edward Wang |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Nature communications |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/ncomms8530 |
| Popis: |
Summary Extensive reprogramming of cellular energy metabolism is a hallmark of cancer. Despite its importance, the molecular mechanism controlling this tumour metabolic shift remains not fully understood. Here we show that 14-3-3σ regulates cancer metabolic reprogramming and protects cells from tumourigenic transformation. 14-3-3σ opposes tumour-promoting metabolic programs by enhancing c-Myc poly-ubiquitination and subsequent degradation. 14-3-3σ demonstrates the suppressive impact on cancer glycolysis, glutaminolysis, mitochondrial biogenesis and other major metabolic processes of tumours. Importantly, 14-3-3σ expression levels predict overall and recurrence-free survival rates, tumour glucose uptake and metabolic gene expression in breast cancer patients. Thus, these results highlight that 14-3-3σ is an important regulator of tumour metabolism, and loss of 14-3-3σ expression is critical for cancer metabolic reprogramming. We anticipate that pharmacologically elevating the function of 14-3-3σ in tumours could be a promising direction for targeted anti-cancer metabolism therapy development in future. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
