The Relationship of Baseline Prostate Specific Antigen and Risk of Future Prostate Cancer and Its Variance by Race
| Autor: | Komal Mehta, Daniel P. Verges, William Atallah, Jeffrey P. Weiss, David Schreiber, Jeremy Weedon, William A. Sterling, Hasan Dani, Nicholas T. Karanikolas |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Prostate biopsy Biopsy Population 030232 urology & nephrology Urology Veterans Health urologic and male genital diseases Logistic regression White People 03 medical and health sciences Prostate cancer 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans Mass Screening education Baseline (configuration management) Veterans Affairs Aged education.field_of_study medicine.diagnostic_test business.industry Prostatic Neoplasms General Medicine Middle Aged Prostate-Specific Antigen medicine.disease Prognosis United States Black or African American Prostate-specific antigen 030220 oncology & carcinogenesis business |
| Zdroj: | Journal of the National Medical Association. 109(1) |
| ISSN: | 0027-9684 |
| Popis: | Several studies suggest that a baseline prostate specific antigen (PSA) measured in young men predicts future risk of prostate cancer. Considering recent recommendations against PSA screening, high-risk populations (e.g. black men, men with a high baseline PSA) may be particularly vulnerable in the coming years. Thus, we investigated the relationship between baseline PSA and future prostate cancer in a black majority-minority urban population.A retrospective analysis was performed of the prostate biopsy database (n = 994) at the Brooklyn Veterans Affairs Hospital. These men were referred to urology clinic for elevated PSA and biopsied between 2007 and 2014. Multivariate logistic regression was used to predict positive prostate biopsy from log-transformed baseline PSA, race (black, white, or other), and several other variables.The majority of men identified as black (50.2%). Median age at time of baseline PSA and biopsy was 58.6 and 64.8, respectively. Median baseline PSA was similar among black men and white men (2.70 vs 2.91 for black men vs white men, p = 0.232). Even so, black men were more likely than white men to be diagnosed with prostate cancer (OR 1.62, p 0.0001). Black men less than age 70 were at particularly greater risk than their white counterparts. Baseline PSA was not a statistically significant predictor of future prostate cancer (p = 0.101).Black men were more likely to be diagnosed with prostate cancer than were white men, despite comparable baseline PSA. In our pre-screened population at the urology clinic, a retrospective examination of baseline PSA did not predict future prostate cancer. |
| Databáze: | OpenAIRE |
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