Maternal exposure to procymidone has no effects on fetal external genitalia development in male rabbit fetuses in a modified developmental toxicity study
| Autor: | Noriyuki Kishimoto, Hashihiro Higuchi, Satoshi Kawamura, Kunifumi Inawaka |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Sex Differentiation animal structures Offspring Developmental toxicity Preputial gland Genitalia Male Biology Toxicology Andrology Bridged Bicyclo Compounds Species Specificity Pregnancy Internal medicine Toxicity Tests medicine Animals skin and connective tissue diseases Maternal-Fetal Exchange Fetus Sexual differentiation Dose-Response Relationship Drug urogenital system medicine.disease Fungicides Industrial Rats Endocrinology Maternal Exposure Hypospadias embryonic structures Gestation Female Rabbits |
| Zdroj: | The Journal of Toxicological Sciences. 35:299-307 |
| ISSN: | 1880-3989 0388-1350 |
| DOI: | 10.2131/jts.35.299 |
| Popis: | This study was conducted to evaluate the effects of procymidone (PCM) on development of male rabbit fetal external genitalia. PCM was administered once daily by gavage at dose levels of 0 (control) and 125mg/kg/day to pregnant rabbits from gestation day 6 through 28 and fetal external genitalia was observed in detail. This treatment period covered the critical stage of sexual differentiation of fetal external genitalia in rabbits. In the maternal animals, food consumption was reduced in the PCM group. There were no effects of PCM on maternal caesarean sectioning data or fetal external observations. In fetal external genitalia observations, there were no significant differences between the control and PCM treatment group in any of the following parameters: ano-genital distance (AGD), phallus boundary-genital distance, diameter of preputial lamella, ventral gap of preputial lamella, or ventral gap to diameter ration of preputial lamella, though severe feminization such as decreasing of AGD and hypospadias in male rat offspring at the dose level of 125 mg/kg of PCM were reported. These results suggest that PCM has no effect on fetal external genitalia development in male rabbit fetuses, and species difference of developmental effects of PCM on sexual differentiation exists. |
| Databáze: | OpenAIRE |
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