Synthesis and evaluation of antitrypanosomal activity of some thiosemicarbazide derivatives of 1-butyl-6-fluoro-7-morpholino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Autor:	Andrzej Gzella, Michael Berninger, Ulrike Holzgrabe, Andriy Pyrih, Roman Lesyk
Rok vydání:	2018
Předmět:	chemistry.chemical_classification Morpholino Carboxylic acid 030231 tropical medicine Organic Chemistry 01 natural sciences Medicinal chemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry 03 medical and health sciences 0302 clinical medicine chemistry X ray analysis Heterocyclic derivatives
Zdroj:	Synthetic Communications. 48:1883-1891
ISSN:	1532-2432 0039-7911
Popis:	The synthesis of thiosemicarbazide of 1-butyl-6-fluoro-7-morpholino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid as well as its heterocyclic derivatives – 1,3,4-thiadiazole and 1,2,4-triazole are described; the modification of proper 1,2,4-triazole derivative by maleimides is also presented. Spectral properties of the prepared compounds and X-ray analysis for the selected compounds were studied. For the compounds antitrypanosomal potential and the toxicity were determined.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07e86416871344e63d8f87fd5fbb864 https://doi.org/10.1080/00397911.2018.1476889 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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