A silver complex of hyaluronan-lipoate (SHLS12): Synthesis, characterization and biological properties
| Autor: | Sergio Paoletti, Rita Gianni, Marco Bosco, Antonia Trevisan, Matteo Fabbian, Eleonora Marsich, Luca Stucchi, Pasquale Sacco, Fabrizio Picotti, Alessandra Sechi |
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| Přispěvatelé: | Sacco, Pasquale, Sechi, Alessandra, Trevisan, Antonia, Picotti, Fabrizio, Gianni, Rita, Stucchi, Luca, Fabbian, Matteo, Bosco, Marco, Paoletti, Sergio, Marsich, Eleonora |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Materials Chemistry2506 Metals and Alloys
Silver Biocompatibility Conductometry Polymers and Plastics Biocompatible Materials 02 engineering and technology 010402 general chemistry 01 natural sciences Mice chemistry.chemical_compound Silver complex In vivo Hyaluronidase Hyaluronic acid Materials Chemistry medicine Animals Humans Bacteria barrier effect Gel Hyaluronan Hyaluronan-lipoate Organic Chemistry Hyaluronic Acid chemistry.chemical_classification Materials Chemistry2506 Metals and Alloy Thioctic Acid Biofilm Biomaterial 3T3 Cells 021001 nanoscience & nanotechnology Anti-Bacterial Agents 0104 chemical sciences Enzyme chemistry Biochemistry Biofilms 0210 nano-technology Gels medicine.drug |
| Popis: | In this study we present a novel silver complex of hyaluronan-lipoate (SHLS12) in a gel-state form. NMR analysis, conductometry and elemental analysis demonstrated stable non-covalent interactions between silver ions and the polysaccharide-lipoate backbone, whereas rheological investigations confirmed its gel-like physical-chemical behavior. Biological studies showed the ability of SHLS12 to exert a straightforward activity against different bacterial strains grown in sessile/planktonic state. The biocompatibility was also proved toward two eukaryotic cell lines. By considering both its ability to preserve antibacterial properties when exposed to the serum protein BSA and its low susceptibility to be degraded by hyaluronidase enzyme, this novel complex may be considered as a promising biomaterial for future in vivo applications. |
| Databáze: | OpenAIRE |
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