Polymorphisms of interferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population
| Autor: | Naoto Keicho, Nguyen Chi Phi, Minako Hijikata, Le Dang Ha, Takehiko Sasazuki, Satoru Itoyama, Vo Van Ban, Ikumi Matsushita, Teruo Kirikae, Fumiko Kirikae, Hoang Thuy Long, Hideki Yanai, Tran Quy, Emi Hamano, Tadatoshi Kuratsuji |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Myxovirus Resistance Proteins Linkage disequilibrium Adolescent Genotype Oligoadenylate synthetase 1 Population Biophysics Single-nucleotide polymorphism Biology Severe Acute Respiratory Syndrome Biochemistry Article Exon Gene Frequency GTP-Binding Proteins 2' 5'-Oligoadenylate Synthetase Humans SNP Genetic Predisposition to Disease Polymorphism skin and connective tissue diseases education Molecular Biology Allele frequency Myxovirus resistance-A Aged SARS associated coronavirus education.field_of_study Polymorphism Genetic fungi Promoter Cell Biology Middle Aged Virology Association study body regions Vietnam Interferon Female |
| Zdroj: | Biochemical and Biophysical Research Communications |
| ISSN: | 0006-291X |
| Popis: | We hypothesized that host antiviral genes induced by type I interferons might affect the natural course of severe acute respiratory syndrome (SARS). We analyzed single nucleotide polymorphisms (SNPs) of 2′,5′-oligoadenylate synthetase 1 (OAS-1), myxovirus resistance-A (MxA), and double-stranded RNA-dependent protein kinase in 44 Vietnamese SARS patients with 103 controls. The G-allele of non-synonymous A/G SNP in exon 3 of OAS-1 gene showed association with SARS (p = 0.0090). The G-allele in exon 3 of OAS-1 and the one in exon 6 were in strong linkage disequilibrium and both of them were associated with SARS infection. The GG genotype and G-allele of G/T SNP at position −88 in the MxA gene promoter were found more frequently in hypoxemic group than in non-hypoxemic group of SARS (p = 0.0195). Our findings suggest that polymorphisms of two IFN-inducible genes OAS-1 and MxA might affect susceptibility to the disease and progression of SARS at each level. |
| Databáze: | OpenAIRE |
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