Heterogeneity and complexity of the prostate epithelium: new findings from single-cell RNA sequencing studies
| Autor: | Michael M. Shen, Laura Crowley |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cancer Research Prostate Diseases Cell Population Biology Article Epithelium Mice Prostate medicine Animals Humans Cell Lineage education Progenitor education.field_of_study Sequence Analysis RNA Cancer Prostatic Neoplasms medicine.disease Organoids medicine.anatomical_structure Oncology Cancer research Stem cell Single-Cell Analysis |
| Zdroj: | Cancer Lett |
| Popis: | The recent advent of single-cell RNA-sequencing technology has provided new fundamental insights into the heterogeneity of the prostate epithelium. Several independent studies have described extensive heterogeneity of the luminal epithelial compartment, including a major division between a novel population of luminal cells located in the proximal region of the prostate ducts versus luminal cells located more distally. Proximal luminal cells as well as novel periurethral cells display increased progenitor potential in organoid culture and tissue reconstitution assays, but not in lineage-tracing analyses during prostate homeostasis, suggesting context-dependent plasticity of these populations. Here we describe and synthesize recent findings regarding the epithelial cell populations in the mouse prostate, draw comparisons to the human prostate, and address the relevance of these findings to prostate diseases and cancer. |
| Databáze: | OpenAIRE |
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