Cadmium oral bioavailability is affected by calcium and phytate contents in food: Evidence from leafy vegetables in mice
| Autor: | Albert L. Juhasz, Xiao-San Luo, Gang Li, Rong-Yue Xue, Meng-Ya Li, Jia-Hui Liang, Ning Wang, Han Ning, Meng-Yu Wang, Lena Q. Ma, Hong-Bo Li |
|---|---|
| Přispěvatelé: | Wang, Meng Yu, Li, Meng Ya, Ning, Han, Xue, Rong Yue, Liang, Jia Hui, Wang, Ning, Luo, Xiao San, Li, Gang, Juhasz, Albert L, Ma, Lena Q, Li, Hong Bo |
| Rok vydání: | 2022 |
| Předmět: |
Cadmium
calcium Environmental Engineering biology cadmium Health Toxicology and Mutagenesis chemistry.chemical_element Amaranth Absorption (skin) Calcium biology.organism_classification Pollution Bioavailability chemistry.chemical_compound chemistry phytate Environmental Chemistry Spinach Food science Leafy vegetables leafy vegetables Health risk bioavailability Waste Management and Disposal |
| Zdroj: | Journal of Hazardous Materials. 424:127373 |
| ISSN: | 0304-3894 |
| DOI: | 10.1016/j.jhazmat.2021.127373 |
| Popis: | To test high cadmium (Cd) concentration may not be high in health risk when considering Cd bioavailability, we assessed variation of Cd relative bioavailability (RBA, relative to CdCl2) using a mouse assay for 14 vegetables of water spinach, amaranth, and pakchoi. Cadmium concentration varied from 0.13 ± 0.01–0.37 ± 0.00 μg g–1 fw. Cadmium-RBA also varied significantly from 22.9 ± 2.12–77.2 ± 4.46%, however, the variation was overall opposite to that of Cd concentration, as indicated by a strong negative correlation between Cd-RBA and Cd concentration (R2 = 0.43). Based on both Cd concentration and bioavailability, the identified high-Cd pakchoi variety resulted in significantly lower Cd intake than the high-Cd varieties of water spinach and amaranth (4.74 ± 0.05 vs. 10.1 ± 0.54 and 8.03 ± 0.04 μg kg–1 bw week–1) due to significantly lower Cd-RBA (22.9 ± 2.12 vs. 77.2 ± 4.46 and 51.3 ± 2.93%). The lower Cd-RBA in pakchoi was due to its significantly higher Ca and lower phytate concentrations, which facilitated the role of Ca in inhibiting intestinal Cd absorption. This was ascertained by observation of decreased Cd-RBA (90.5 ± 12.0% to 63.5 ± 5.53%) for a water spinach when elevating its Ca concentration by 30% with foliar Ca application. Our results suggest that to assess food Cd risk, both total Cd and Cd bioavailability should be considered. Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect