Opportunistic infections among individuals with HIV-1/AIDS in the highly active antiretroviral therapy era at a Quaternary Level Care Teaching Hospital
| Autor: | Célia Franco, Katia Jaira Galisteu, Andrea Regina de Souza Baptista, Adriana Antônia da Cruz Furini, Arlindo Schiesari Júnior, Luciana Ventura Cardoso, Claudia Bernardi Cesarino, Ricardo Luiz Dantas Machado |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 medicine.disease_cause Esophageal candidiasis Young Adult Acquired immunodeficiency syndrome (AIDS) Internal medicine Antiretroviral Therapy Highly Active Epidemiology medicine Prevalence HBV Humans Opportunistic infections Hospitals Teaching Retrospective Studies Hepatitis B virus AIDS-Related Opportunistic Infections business.industry Medical record HIV Retrospective cohort study Middle Aged Viral Load medicine.disease CD4 Lymphocyte Count Pneumonia Infectious Diseases Cross-Sectional Studies Immunology HCV HIV-1 Parasitology Female business Viral load Brazil |
| Zdroj: | Revista da Sociedade Brasileira de Medicina Tropical v.48 n.2 2015 Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT) instacron:SBMT Revista da Sociedade Brasileira de Medicina Tropical, Volume: 48, Issue: 2, Pages: 149-156, Published: APR 2015 Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 2, Pp 149-156 (2015) |
| Popis: | INTRODUCTION : In this study, clinical-laboratory and epidemiological characteristics are described for a group of 700 individuals with HIV (human immunodeficiency virus)/AIDS (acquired immunodeficiency syndrome) in the ART (antiretroviral therapy) era at a teaching hospital that provides a quaternary level of care, with an emphasis on opportunistic infections (OIs), co-infections and immune profile. METHODS : A retrospective cross-sectional study of AIDS cases was conducted from 1998 to 2008 by reviewing medical records from the Base Hospital/FUNFARME (Fundação Faculdade Regional de Medicina), São José do Rio Preto, São Paulo, Brazil. RESULTS: The individuals were 14 to 75 years of age, and 458 were males. Heterosexuals accounted for 31.1% of all patients. Eighty-three percent were on ART, and 33.8% of those presented difficulties with treatment adherence. OIs were analyzed from medical records, and Pneumocystis jiroveci pneumonia was the most prevalent, regardless of the LTCD4+ (TCD4+ Lymphocytes) levels. Individuals whose viral loads were ≥10,000 showed a 90% greater chance of neurotoxoplasmosis. For P. jiroveci pneumonia, neurotoxoplasmosis, esophageal candidiasis, pulmonary tuberculosis and neurocryptococcosis, the chances of infection were higher among patients with LTCD4+ levels below 200 cells/mm3. HIV/hepatitis C virus (HCV) and HIV/hepatitis B virus (HBV) co-infections were significantly associated with death. CONCLUSIONS : OIs remain frequent in the ART era even in populations where the access to medical care is considered satisfactory. |
| Databáze: | OpenAIRE |
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